MR OF CEREBRAL OXYGENATION IN ISCHEMIA

应聘者目标和职业发展计划：应聘者是 介入神经放射科医生的长期目标是成为 具有临床责任的学术领域的独立研究员 医疗中心。应聘者已经学习了使用 正电子发射断层扫描(PET)对脑血流动力学和血流动力学的研究 新陈代谢测量。这一奖项将确保专门的时间和 发展知识和技能基础所需的指导 这是成功的长期调查所必需的。这个基金会将 在建议的三年内通过(1)获得 加深对脑血管病理生理学的认识和运用 通过参与美国国立卫生研究院资助的项目进行宠物研究 项目；(2)学习生理磁共振方面的高级技能 (MR)测量和(3)为开发收集初步数据 一个独立的项目 环境：在这两种PET的可用性方面，环境是独一无二的 以及专业知识和技术先生。候选人的赞助人很好 被公认为脑血管独立调查者 使用正电子发射计算机断层扫描进行病理生理学检查。同样，共同发起人是一家 积极的磁共振研究小组，因在生理学磁共振方面的工作而受到认可 申请。利用正电子发射计算机断层扫描研究大脑的基金项目 急性神经损伤患者的血流动力学和代谢 将在该奖项的三年任期内进行。 研究建议：本研究的主要目的是调查MR在 脑局部氧摄取分数(ROEF)的测定 在人类身上。初步数据表明，这些测量结果 具有重要的临床意义。要检验的主要假设 脱氧血红蛋白敏感的磁共振MAP(称为血氧水平 依赖、粗体或R2*图)，在对血容量进行校正后，将 确定Roef的区域增长。首先，MR的准确性 将评估脑血容量(RCBV)的测量。这 将通过配对的MR和PET研究在30名患者中完成 颈动脉闭塞。其次，直接测量Roef的关系 颈静脉A-VDO2取样和rCBV校正血氧水平依赖关系 磁共振地图将在一系列猕猴身上进行严格的检查 实验。最后，假设血液中的含氧量 校正rCBV的依赖地图将准确识别区域 30名颈动脉稳定的患者将检测Roef的变化 应用正电子发射计算机断层扫描和磁共振成像研究咬合

Candidate Goals and Career Development Plan: The candidate is an interventional neuroradiologist with a long term goal of becoming an independent investigator with clinical responsibilities in an academic medical center. The candidate has learned basic skills in the use of Positron Emission Tomography (PET) for cerebral hemodynamic and metabolic measurements. This award will secure the dedicated time and guidance needed to develop the foundation of knowledge and skills required for successful long term investigation. This foundation will be built over the proposed three years of the award by (1) gaining a deeper understanding of cerebrovascular pathophysiology and the use of PET for it's study through participation in a NIH funded Program Project; (2)learning advanced skills in physiologic magnetic resonance (MR) measurements and (3) gathering preliminary data for the development of an independent project Environment: The environment is unique in the availability of both PET and MR expertise and technology. The candidate's sponsor is well recognized as an independent investigator of cerebrovascular pathophysiology using PET. Similarly, the co-sponsor is director of an active MR research group, recognized for work in physiologic MR applications. A funded Program Project using PET to study cerebral hemodynamics and metabolism in patients with acute neurologic injury will be underway during the three year term of this award. Research Proposal: The primary aim is to investigate the use of MR for the measurement of regional cerebral oxygen extraction fraction (rOEF) in humans. Preliminary data indicate that these measurements have important clinical significance. The primary hypothesis to be tested is that deoxyhemoglobin sensitive MR maps (known as blood oxygen level dependent, BOLD or R2* maps), after correction for blood volume, will identify regional increases in rOEF. First, the accuracy of MR measurements of cerebral blood volume (rCBV) will be assessed. This will be accomplished with paired MR and PET studies in 30 patients with carotid occlusion. Next, the relationship of rOEF measured by direct jugular A-VDO2 sampling and rCBV corrected blood oxygen level dependent MR maps will be rigorously examined in a series of Macaque monkey experiments. Finally, the hypothesis that a blood oxygen level dependent map corrected for rCBV will accurately identify regional changes in rOEF will be tested in 30 patients with stable carotid occlusion studied with PET and MR.