Washington University SPOTRIAS Center

华盛顿大学 SPOTRIAS 中心

• 批准号: 8267643
• 负责人: COLIN Pieter DERDEYN
• 金额: $ 218.55万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8267643
• 关键词: Acute; Aneurysmal Subarachnoid Hemorrhages; Attention; Basic Science; Biostatistics Core; Blood Vessels; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrum; Clinical; Clinical Research; Collaborations; DNA; Data Set; Diagnosis; Early Diagnosis; Early treatment; Emergency Medicine; Extramural Activities; Funding; Future; Goals; Hour; Image; Infarction; Institution; Intravenous; Investigation; Ischemia; Lead; Link; Methods; National Institute of Neurological Disorders and Stroke; Neurology; Patient Care; Patients; Pilot Projects; Recording of previous events; Research Personnel; Resources; Sampling; Scientist; Sequence Determination; Serum; Stroke; Tissues; Training; Translational Research; United States National Institutes of Health; Universities; Washington; acute stroke; career; career development; data management; experience; hindbrain; injured; intravenous administration; medical specialties; novel; novel strategies; outreach; programs; repository

The overall aim of this specialized program of translational research in acute stroke (SPOTRIAS) application is to develop new approaches to the diagnosis and treatment of acute stroke patients. The NINDS has recognized the need to develop regional interdisciplinary centers dedicated to advancing the early treatment of patients with acute stroke: they have invited applications for specialized programs in translational research in acute stroke (SPOTRIAS). The expressed intent of the SPOTRIAS program is "to support a collaboration of clinical researchers from different specialties whose collective efforts will lead to new approaches to early diagnosis and treatment of acute stroke patients". Our SPOTRIAS proposal is in direct support of this goal. The present proposal draws on several clinical and research strengths of our institution. We have built an active acute stroke team that has achieved impressive results in the rapid administration of intravenous tPA. This was accomplished through an interdisciplinary effort led by Emergency Medicine and Vascular Neurology. We serve as a major referral center for acute cerebrovascular disease and treat nearly 150 patients per year with aneurysmal subarachnoid hemorrhage. Finally, we have a large number of experienced, NIH-funded investigators dedicated to basic, translational, and clinical research in cerebrovascular disease. This multi-disciplinary group has a long-standing history of collaboration. This proposal builds on this experience and will allow us to focus attention and resources on advancing the care of patients with acute stroke. It will help to support our outreach efforts and maintain our acute stroke treatment network (Patient Access Core). It will help us train future clinician-scientists for careers in acute cerebrovascular disease (Career Development Core). It will support our efforts to maintain a repository of linked clinical information, imaging, and serum and DNA samples of stroke patients (Patient Access Core, Biospecimen Core, Data Management and Biostatistics Core, and Imaging Core). This unique dataset will be available to intramural and extramural SPOTRIAS investigators for preliminary investigation. We will investigate the effects of statins on cerebral blood flow, ischemia, and autoregulatory function in patients with aneurysmal subarachnoid hemorrhage (Project 1). We hope to expand the window and indications for iv-tPA in Project 2, a pilot study of intravenous tPA for patients with hindbrain stroke presenting with 24 hours of onset. Finally, we will evaluate a novel MR sequence for the determination of cerebral oxygenation (Project 3). This has promise as a method to reliably identify injured tissue that will progress to infarction without therapy.

该转化研究在急性卒中（SPOTRIAS）应用的专业计划的总体目标是开发新的方法来诊断和治疗急性卒中患者。NINDS已经认识到有必要发展区域跨学科中心，致力于推进急性卒中患者的早期治疗：他们已经邀请申请急性卒中转化研究（SPOTRIAS）的专业项目。SPOTRIAS计划的明确意图是“支持来自不同专业的临床研究人员的合作，他们的集体努力将导致急性中风患者早期诊断和治疗的新方法”。我们的SPOTRIAS提案直接支持这一目标。本提案借鉴了我们机构的几个临床和研究优势。我们已经建立了一个活跃的急性中风团队，在静脉注射tPA的快速管理方面取得了令人印象深刻的结果。这是通过急诊医学和血管神经病学领导的跨学科努力完成的。我们是急性脑血管病的主要转诊中心，每年治疗近150例蛛网膜下腔出血患者。最后，我们有大量经验丰富的NIH资助的研究人员致力于脑血管疾病的基础，转化和临床研究。这个跨学科的小组有着悠久的合作历史。这项建议建立在这一经验的基础上，将使我们能够集中注意力和资源，推进急性卒中患者的护理。这将有助于支持我们的外展工作，并维持我们的急性中风治疗网络（患者访问核心）。它将帮助我们培养未来的临床科学家在急性脑血管疾病的职业生涯（职业发展核心）。它将支持我们努力维护卒中患者的相关临床信息、成像以及血清和DNA样本的存储库（患者访问核心、生物样本核心、数据管理和生物统计核心以及成像核心）。这一独特的数据集将提供给院内外SPOTRIAS研究者进行初步调查。我们将研究他汀类药物对蛛网膜下腔出血患者脑血流、缺血和自身调节功能的影响（项目1）。我们希望在项目2中扩大静脉tPA的窗口和适应症，这是一项静脉tPA治疗起病24小时的后脑卒中患者的初步研究。最后，我们将评估一种新的MR序列用于确定脑氧合（项目3）。这有希望作为一种方法，可靠地识别受伤的组织，将进展到梗死没有治疗。

项目成果

Yield of catheter angiography after computed tomography negative, lumbar puncture positive subarachnoid hemorrhage [corrected].

计算机断层扫描阴性、腰椎穿刺阳性蛛网膜下腔出血后导管血管造影的产量[已纠正]。

• DOI: 10.1161/strokeaha.113.001234
• 发表时间: 2013
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Wallace,AdamN;Dines,JeffreyN;Zipfel,GregoryJ;Derdeyn,ColinP
• 通讯作者: Derdeyn,ColinP

A case-control study of the effectiveness of tissue plasminogen activator on 6 month patients--reported outcomes and health care utilization.

组织纤溶酶原激活剂对 6 个月患者有效性的病例对照研究——报告结果和医疗保健利用。

• DOI: 10.1016/j.jstrokecerebrovasdis.2014.07.049
• 发表时间: 2014
• 期刊: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
• 作者: Lang,CatherineE;Bland,MarghurettaD;Cheng,Nuo;Corbetta,Maurizio;Lee,Jin-Moo
• 通讯作者: Lee,Jin-Moo

Reducing door-to-needle times using Toyota's lean manufacturing principles and value stream analysis.

• DOI: 10.1161/strokeaha.112.670687
• 发表时间: 2012-12
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Ford AL;Williams JA;Spencer M;McCammon C;Khoury N;Sampson TR;Panagos P;Lee JM
• 通讯作者: Lee JM

Clinically relevant reperfusion in acute ischemic stroke: MTT performs better than Tmax and TTP.

• DOI: 10.1007/s12975-014-0325-2
• 发表时间: 2014-06
• 期刊: TRANSLATIONAL STROKE RESEARCH
• 影响因子: 6.9
• 作者: Ford, Andria L.;An, Hongyu;Kong, Linglong;Zhu, Hongtu;Vo, Katie D.;Powers, William J.;Lin, Weili;Lee, Jin-Moo
• 通讯作者: Lee, Jin-Moo

Controversy: does prevention of vasospasm in subarachnoid hemorrhage improve clinical outcome?

争议：预防蛛网膜下腔出血中的血管痉挛是否可以改善临床结果？

• DOI: 10.1161/strokeaha.111.000008
• 发表时间: 2013
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Diringer,MichaelN