PREVENTIVE ONCOLOGY ACADEMIC AWARD

预防肿瘤学学术奖

• 批准号: 6173338
• 负责人: ANTHONY J ALBERG
• 金额: $ 9.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-07 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6173338
• 关键词: behavioral /social science research tag; cancer prevention; clinical research; colon neoplasms; genetic polymorphism; human genetic material tag; human subject; lifestyle; molecular oncology; neoplasm /cancer epidemiology; neoplasm /cancer genetics; nutrition related neoplasm /cancer; nutrition related tag; smoking; tobacco abuse

DESCRIPTION: (Applicant's Description) The proposed plan will provide me with a foundation for a long-term career in cancer epidemiology and prevention. The pathway outlined toward this goal is to gain proficiency in molecular epidemiology, which holds promise to advance our knowledge of both cancer etiology as well as cancer prevention, adding to my established skill in epidemiologic methods. A two-pronged approach of education and research is proposed. The educational plan is designed to: 1) expand my knowledge of molecular epidemiology and 2) enhance my teaching and communication skills. The former goal will be addressed through course work, discussion-oriented forums, and be reinforced by the research program. Toward the latter goal, I will participate in teaching classes on epidemiologic methods and cancer epidemiology. I will also work in community setting to enhance skills in communicating with decision-makers. The research plan consists of three studies with a focus on colon cancer. Phase 1 is a prospective cohort study of cigarette smoking in relation to the risk of colon cancer. Phase 2 is a nested case control study to evaluate the relationships of cigarette smoking, diet, and polymorphisms in genes that encode carcinogen metabolizing enzymes in relation to colon cancer risk. Phase 3 is a cross-sectional study of the prevalence of lifestyle practices and cancer prevention behaviors that will lead to the development of a cancer control plan. The results of this research program, while contributing to our knowledge of the etiology of colon cancer, will be applicable susceptible subgroups of the population who may be at greatest risk. By strengthening my background in molecular epidemiology, the proposal plan will build upon previous experience in cancer epidemiology and prevention and will enable me to engage in a broad range of research geared toward the prevention of cancer.

描述：（申请人的描述）拟议的计划将为我提供 为癌症流行病学领域的长期职业生涯奠定了基础 预防。 实现这一目标的途径是熟练掌握 分子流行病学，有望增进我们对这两种疾病的了解 癌症病因学以及癌症预防，增强了我的既定技能 在流行病学方法中。 教育和研究双管齐下 被提议。 教育计划旨在：1）扩展我的分子知识 流行病学；2）提高我的教学和沟通技巧。 这 先前的目标将通过以讨论为导向的课程作业来实现 论坛，并通过研究计划得到加强。 为了后一个目标， 我将参加流行病学方法和癌症的教学课程 流行病学。 我还将在社区环境中工作，以提高以下方面的技能 与决策者沟通。 该研究计划由三项研究组成，重点关注结肠癌。 第一阶段是一项关于吸烟与吸烟相关的前瞻性队列研究 结肠癌的风险。 第二阶段是一项巢式病例对照研究 评估吸烟、饮食和多态性之间的关系 编码与结肠相关的致癌物代谢酶的基因 癌症风险。 第三阶段是一项横断面研究，调查患病率 生活方式习惯和癌症预防行为将导致 制定癌症控制计划。 该研究计划的结果， 在有助于我们了解结肠癌病因的同时， 适用的易感人群最多可能是 风险。 通过加强我在分子流行病学方面的背景，提案计划 将建立在癌症流行病学和预防方面的先前经验的基础上 并使我能够从事广泛的研究 预防癌症。