PREVENTIVE ONCOLOGY ACADEMIC AWARD

预防肿瘤学学术奖

• 批准号: 6522383
• 负责人: ANTHONY J ALBERG
• 金额: $ 9.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-07 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6522383
• 关键词: behavioral /social science research tag; cancer prevention; clinical research; colon neoplasms; genetic polymorphism; human genetic material tag; human subject; lifestyle; molecular oncology; neoplasm /cancer epidemiology; neoplasm /cancer genetics; nutrition related neoplasm /cancer; nutrition related tag; smoking; tobacco abuse

DESCRIPTION: (Applicant's Description) The proposed plan will provide me with a foundation for a long-term career in cancer epidemiology and prevention. The pathway outlined toward this goal is to gain proficiency in molecular epidemiology, which holds promise to advance our knowledge of both cancer etiology as well as cancer prevention, adding to my established skill in epidemiologic methods. A two-pronged approach of education and research is proposed. The educational plan is designed to: 1) expand my knowledge of molecular epidemiology and 2) enhance my teaching and communication skills. The former goal will be addressed through course work, discussion-oriented forums, and be reinforced by the research program. Toward the latter goal, I will participate in teaching classes on epidemiologic methods and cancer epidemiology. I will also work in community setting to enhance skills in communicating with decision-makers. The research plan consists of three studies with a focus on colon cancer. Phase 1 is a prospective cohort study of cigarette smoking in relation to the risk of colon cancer. Phase 2 is a nested case control study to evaluate the relationships of cigarette smoking, diet, and polymorphisms in genes that encode carcinogen metabolizing enzymes in relation to colon cancer risk. Phase 3 is a cross-sectional study of the prevalence of lifestyle practices and cancer prevention behaviors that will lead to the development of a cancer control plan. The results of this research program, while contributing to our knowledge of the etiology of colon cancer, will be applicable susceptible subgroups of the population who may be at greatest risk. By strengthening my background in molecular epidemiology, the proposal plan will build upon previous experience in cancer epidemiology and prevention and will enable me to engage in a broad range of research geared toward the prevention of cancer.

描述：（申请人描述）提议的计划将提供给我

项目成果

Less efficient g2-m checkpoint is associated with an increased risk of lung cancer in African Americans.

效率较低的 g2-m 检查点与非裔美国人患肺癌的风险增加有关。

• DOI: 10.1158/0008-5472.can-05-1003
• 发表时间: 2005
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Zheng,Yun-Ling;Loffredo,ChristopherA;Alberg,AnthonyJ;Yu,Zhipeng;Jones,RaymondT;Perlmutter,Donna;Enewold,Lindsey;Krasna,MarkJ;Yung,Rex;Shields,PeterG;Harris,CurtisC
• 通讯作者: Harris,CurtisC

Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls.

博来霉素诱导的染色体断裂作为肺癌的风险标记：一项针对人群和医院对照的病例对照研究。

• DOI: 10.1093/carcin/24.2.269
• 发表时间: 2003
• 期刊: Carcinogenesis
• 影响因子: 4.7
• 作者: Zheng,Yun-Ling;Loffredo,ChristopherA;Yu,Zhipeng;Jones,RaymondT;Krasna,MarkJ;Alberg,AnthonyJ;Yung,Rex;Perlmutter,Donna;Enewold,Lindsey;Harris,CurtisC;Shields,PeterG
• 通讯作者: Shields,PeterG

Household exposure to passive cigarette smoking and serum micronutrient concentrations.

• DOI: 10.1093/ajcn/72.6.1576
• 发表时间: 2000-12
• 期刊: The American journal of clinical nutrition
• 作者: A. Alberg;Joyce C Chen;Hongxin Zhao;S. Hoffman;G. Comstock;K. J. Helzlsouer

Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin.

血清脱氢表雄酮和硫酸脱氢表雄酮与黑色素瘤或皮肤鳞状细胞癌的风险。

• 发表时间: 2001
• 期刊: Anticancer research.
• 作者: Alberg,AJ;Gordon,GB;Genkinger,JM;Hoffman,SC;Selvin,E;Comstock,GW;Helzlsouer,KJ
• 通讯作者: Helzlsouer,KJ