VISCERAL ADIPOSE TISSUE AND COLORECTAL NEOPLASIA

结直肠癌(CRC)是一个重大的公共卫生问题。 由于晚期结直肠癌的治疗有限，结直肠癌的前景 控制必须注重及早发现和预防。强壮 间接证据表明，CRC是从一种前体发展而来的 病变，腺瘤性息肉。因为个体的数量 息肉远远超过患癌症的人数，在 CRC控制必须侧重于提高我们对风险的理解 腺瘤发生和转化的因素 腺瘤转化为结直肠癌。 根据身体质量指数估计的肥胖症一直是 在男性中与结直肠癌风险有关，但在女性中不相关。最新流行病学 数据表明脂肪组织的分布，特别是内脏 脂肪组织(VAT)而不是整体肥胖症，可能是 结直肠癌的重要风险因素。膳食脂肪、肉类和蛋白质的摄入量 也被认为是儿童权利中心的风险因素，但研究 各有不同。例如，多不饱和AS的好处 与饱和脂肪相反的摄入并不是在所有研究中都能观察到的。 之前的调查可能因为使用 测量肥胖或估计膳食脂肪的方法不准确 入口处。生物措施是可取的，因为它们的 精确度。我建议研究脏腑之间的关系 脂肪组织和膳食脂肪摄入量对腺瘤性息肉的影响 结直肠癌的前驱病变。两个久经考验的生物标志物 将采用卓越的重复性和成功的试点测试。 这些研究的结果将很快转化为临床应用。 并可能对未来的预防工作产生重大影响。

Colorectal cancer (CRC) is a significant public health problem. Because treatment of advanced CRC is limited, prospects for CRC control must focus on early detection and prevention. Strong circumstantial evidence suggests that CRC develops from a precursor lesion, the adenomatous polyp. Because the number of individuals with polyps far exceeds the number who develop cancer, advances in CRC control must focus on improving our understanding of the risk factors for developing adenomas and for the transformation of adenomas into colorectal cancers. Obesity, estimated by body mass index, has been consistently linked to CRC risk in men but not in women. Recent epidemiologic data suggest that adipose tissue distribution, and in particular visceral adipose tissue (VAT) rather than overall adiposity, may be an important risk factor for CRC. Dietary fat, meat, and protein intake have also been postulated as risk factors for the CRC but studies have varied. For example, the benefits of polyunsaturated as opposed to saturated fat intake have not been observed in all studies. Previous investigations may have been hampered by using imprecise methodologies to measure obesity or estimate dietary fat intake. Biologic measures are preferable because of their greater precision. I propose to investigate the relationship of visceral adipose tissue and dietary fat intake to adenomatous polyps, the precursor lesion of CRC. Two well established biomarkers with superb reproducibility and successful pilot testing will be employed. Results from these studies will translate rapidly to clinical application and may impact significantly on future prevention efforts.