Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation

下丘脑腹内侧区的雌激素信号调节脂肪组织代谢适应

基本信息

项目摘要

While sexual dimorphisms have been reported in the adipose tissue’s metabolic adaptation to environmental temperature or nutritional challenges, the sex-specific mechanisms regulating adipose tissue’s responses are not fully understood. There is increasing evidence demonstrating that the female sex hormone, estrogen, plays a vital role in sex dimorphic control of adipose tissue metabolism. We and others have consistently shown that central estrogen signaling mediated by estrogen receptor α (ERα) increases sympathetic activity, promotes brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning, and diminishes excessive adiposity. ERα is abundantly expressed in the ventrolateral region of the ventromedial hypothalamus (vlVMH), a sex-dimorphic structure and the only ERα site in the brain that directly modulates BAT thermogenesis. Despite the abundant evidence supporting the role of ERαvlVMH in energy expenditure and metabolic function, it is still unclear whether ERαvlVMH-originated networks respond to environmental challenges, subsequently regulating adipose tissue metabolic adaptations. Here, we aim to test whether estrogen-initiated ERαvlVMH signaling and its downstream circuit contribute to sex dimorphic regulation of adipose tissue metabolic adaptation. The first aim is to determine if ERαvlVMH sex-dimorphically modulates BAT and WAT metabolism in response to temperature or nutritional challenge. The second aim is to determine if the dorsal raphe nucleus (DRN) relays ERαvlVMH neuron signals to adipose tissue to modulate metabolic adaptation. Results from these studies will advance our current understanding of adipose tissue plasticity and adaptation in general. Further, our studies will reveal the brain ERα-originated networks that respond to temperature or nutritional challenges and initiate subsequent changes in adipose tissue metabolism.
虽然在脂肪组织对环境的代谢适应中已经报道了性二态性 温度或营养挑战,调节脂肪组织反应的性别特异性机制是 没有完全理解。越来越多的证据表明,女性性激素,雌激素, 在脂肪组织代谢的性别二态控制中起重要作用。我们和其他人一直表明, 由雌激素受体α(ERα)介导的中枢雌激素信号传导增加交感神经活性,促进 棕色脂肪组织(BAT)产热和白色脂肪组织(WAT)布朗宁,并减少过度 肥胖症ERα在下丘脑腹内侧腹外侧区(vlVMH)大量表达, 性二态结构和脑中唯一直接调节BAT产热的ERα位点。尽管 尽管有大量证据支持ERαvlVMH在能量消耗和代谢功能中的作用,但它仍然是一个重要的研究领域。 不清楚ERα vlVMH起源的网络是否对环境挑战做出反应,随后调节 脂肪组织代谢适应在这里,我们的目的是测试雌激素启动的ERαvlVMH信号传导和 其下游回路有助于脂肪组织代谢适应性二态调节。第一 目的是确定ERαvlVMH是否通过性二态调节BAT和WAT代谢, 温度或营养挑战。第二个目的是确定中缝背核(DRN)是否中继 ERαvlVMH神经元向脂肪组织发出信号以调节代谢适应。这些研究的结果将 推进我们目前对脂肪组织可塑性和适应性的理解。此外,我们的研究 将揭示大脑ERα起源的网络,这些网络对温度或营养挑战做出反应,并启动 脂肪组织代谢的后续变化。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Valeria Cecilia Torres Irizarry其他文献

Valeria Cecilia Torres Irizarry的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

相似海外基金

Depleting Somatostatinergic Neurons Recapitulates Diabetic Phenotypes In Brain and Adipose Tissue
消耗生长抑素能神经元重现大脑和脂肪组织中的糖尿病表型
  • 批准号:
    10536358
  • 财政年份:
    2022
  • 资助金额:
    $ 4.77万
  • 项目类别:
Depleting Somatostatinergic Neurons Recapitulates Diabetic Phenotypes In Brain and Adipose Tissue
消耗生长抑素能神经元重现大脑和脂肪组织中的糖尿病表型
  • 批准号:
    10647698
  • 财政年份:
    2022
  • 资助金额:
    $ 4.77万
  • 项目类别:
The vagus nerve and gut - brain interactions: the underpinnings of successful weight loss surgery through recruitment of Brown Adipose Tissue
迷走神经和肠-脑相互作用:通过招募棕色脂肪组织成功减肥手术的基础
  • 批准号:
    nhmrc : GNT1163039
  • 财政年份:
    2019
  • 资助金额:
    $ 4.77万
  • 项目类别:
    Project Grants
Pathological Significance of TREM2 in Obesity/Diabetes-Related Cognitive Impairment through the Brain-Adipose Tissue Axis
TREM2 通过脑-脂肪组织轴在肥胖/糖尿病相关认知障碍中的病理意义
  • 批准号:
    19K07927
  • 财政年份:
    2019
  • 资助金额:
    $ 4.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The adipose tissue controls ageing of the brain
脂肪组织控制大脑衰老
  • 批准号:
    18K18454
  • 财政年份:
    2018
  • 资助金额:
    $ 4.77万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Brain pathways for neurally-mediated fever: from vagal afferent to sympathetic output to brown adipose tissue via brain
神经介导发烧的大脑通路:从迷走神经传入到交感神经输出,通过大脑到棕色脂肪组织
  • 批准号:
    nhmrc : 426716
  • 财政年份:
    2007
  • 资助金额:
    $ 4.77万
  • 项目类别:
    NHMRC Project Grants
HPA Axis-Dependent Visceral Adipose tissue and brain changes in IBS and related
IBS 及相关疾病中 HPA 轴依赖性内脏脂肪组织和大脑的变化
  • 批准号:
    8733658
  • 财政年份:
  • 资助金额:
    $ 4.77万
  • 项目类别:
HPA Axis-Dependent Visceral Adipose tissue and brain changes in IBS and related
IBS 及相关疾病中 HPA 轴依赖性内脏脂肪组织和大脑的变化
  • 批准号:
    8921180
  • 财政年份:
  • 资助金额:
    $ 4.77万
  • 项目类别:
HPA Axis-Dependent Visceral Adipose tissue and brain changes in IBS and related
IBS 及相关疾病中 HPA 轴依赖性内脏脂肪组织和大脑的变化
  • 批准号:
    9136796
  • 财政年份:
  • 资助金额:
    $ 4.77万
  • 项目类别:
HPA Axis-Dependent Visceral Adipose tissue and brain changes in IBS and related
IBS 及相关疾病中 HPA 轴依赖性内脏脂肪组织和大脑的变化
  • 批准号:
    8539773
  • 财政年份:
  • 资助金额:
    $ 4.77万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了