PROSPECTIVE INVESTIGATION OF PUMONARY EMBOLISM DX II

本研究是一项多中心联合研究，旨在确定螺旋CT增强扫描诊断急性肺栓塞的敏感性、特异性、阳性预测值和阴性预测值。肺栓塞是一种常见的疾病，但经常未被诊断并致死。肺通气/灌注扫描是最常用的检查方法。然而，在72%的疑似PE患者和57%确诊的PE患者中，它们是非诊断性的。目前，肺血管造影术是明确的诊断方法，但由于发病率、不适感、不适感、费用以及社区医院缺乏可获得性，对它的使用还存在一定的犹豫。螺旋CT增强扫描是一种近乎非侵入性的检查，可以通过显示肺动脉血栓的轮廓来明确诊断PE。然而，它在PE的诊断中的作用尚不清楚。尽管空间CT还没有得到充分的验证，但许多医院的医生现在将其作为PE的唯一明确诊断方法，或作为非诊断性肺通气/灌注扫描患者的明确检查。这可能导致过度治疗或治疗不足，两者都有可能出现严重的并发症。螺旋CT在PE诊断中的作用需要准确的血管造影。这一建议的优点是：1)就诊断不足造成的生命损失而言，肺栓塞问题的重要性；2)诊断肺栓塞的新技术的潜在适用性；3)调查小组。

A multi-center collaborative study to determine the sensitivity, specificity, positive predictive value and negative predictive value of contrast enhanced spiral computed tomography (spiral CT) for diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal. Ventilation/perfusion lung scans are the most commonly used test. However, they are non-diagnostic in 72% of patients with suspected PE and in 57% of patients with proven PE. Currently, Pulmonary Angiography is the definitive diagnostic test, but, there is hesitancy to use it because of morbidity, discomfort, discomfort, cost and lack of availability in community hospitals. Contrast enhanced spiral CT is a nearly non-invasive test that offers the possibility of a definitive diagnosis of PE by showing the outline of the thrombus in a pulmonary artery. However, its utility in the diagnosis of PE is unknown. Although spatial CT has not been adequately validated, physicians at many hospitals now use it as a definitive and only diagnostic test for PE, or as a definitive test in patients in whom the ventilation/perfusion lung scan is non-diagnostic. This could lead to over-treatment or under- treatment, of which, both have potential for serious complications. The role of spiral CT in the diagnosis of PE requires an accurate angiography. The strengths of this proposal are: 1) the importance of the problem of PE in terms of lives lost from under-diagnosis 2) the potential applicability of a new technology for the diagnosis of PE that will have widespread availability 3) the investigation team.