Bench, Bedside, Business, and Beyond: innovative solutions for AMR diagnostics

这个名为B2B2B AMRDx的网络汇集了来自大学(长凳)、医院(床边)、营利性(企业)、政府和非营利组织(其他)的各种研究人员，以应对其中的一些挑战。我们拥有人类、动物和环境AMR方面的专业知识，来自20个不同的国家。该网络的目标如下：首先，该网络创建了一个全面的在线AMR诊断开发人员目录(ADDD)，以促进该领域的思想交流。其次，该网络扩展了JPIAMR Seq4AMR虚拟基准平台(VBP)，使诊断开发人员能够系统地评估他们对一系列高质量基因类型(基因组数据)和表型(抗菌素耐药性数据)的诊断，并确定它们的优势和劣势。第三，该网络确定了新的政策方向，通过考虑使用AMR诊断对公众健康的好处，支持诊断技术的开发和采用。这些发展将帮助AMR诊断跨越死亡之谷，并帮助患者。预期的结果：基于AMR Insights的技术页面，建立一个开放的、经过管理的在线AMR诊断开发人员目录(ADDD)。一个研讨会，以Seq4AMR网络(Raphenya等人，2022年)以前的成就为基础，制定VBP的基因型、表型和元数据标准以及伴随的细菌分离物(Raphenya等，2022)用于管理、选择和精选黄金标准NGS数据、表型数据和元数据的系统方法，以及用于VBP的相应细菌分离物。通信、传播和路线图开放获取出版物，描述VBP的内容、格式、格式和路线图和基准集合选择协议。可能的期刊：微生物基因组学或类似物。一个研讨会，旨在制定一项监管途径的提案，使AMR诊断开发人员能够受益于基于其产品的公共健康益处的激励措施。描述拟议政策的开放获取路线图出版物。

The network, B2B2B AMRDx, brings together a diverse group of researchers from universities (bench), hospitals (bedside), for-profits (business), governments and nonprofits (beyond), to tackle some of these challenges. We have expertise in human, animal, and environmental AMR, and come from 20 different countries. The networks goals are as follows.First, the network creates a comprehensive online AMR Diagnostics Developer Directory (ADDD) to facilitate exchange of ideas in the field. Second, the network extends the JPIAMR Seq4AMR Virtual Benchmarking Platform (VBP) to allow diagnostics developers to systematically evaluate their diagnostics on a collection of high-quality genotypes (genomic data) and phenotypes (antimicrobial resistance data) and identify their strengths and weaknesses. Third, the network identifies new policy directions that can support diagnostics development and adoption by accounting for the public health benefits of using AMR diagnostics. These developments will help AMR diagnostics cross the "valley of death" and help patients.Expected outcomes:An open, curated online AMR diagnostics developer directory (ADDD), building on AMR Insights' Technology Pages.A workshop to develop the standards for genotypes, phenotypes, and metadata, as well as the accompanying bacterial isolates for the VBP, building on previous achievements of the Seq4AMR network (Raphenya et al, 2022)A systematic approach for the management, selection and curation of gold standard NGS data, phenotype data, and metadata, as well as the corresponding bacterial isolates for the VBP.Communication, dissemination and roadmap open-access publication describing the VBP contents, its format, and the benchmark set selection protocol. Possible journals: Microbial Genomics or similar.A workshop to develop a proposal for a regulatory pathway to allow AMR diagnostics developers to benefit from incentives based on the public health benefits of their products.An open-access roadmap publication describing the proposed policy.