Bridging bench to bedside with aneurotechnology cross-development platform

通过神经技术交叉开发平台将工作台与床边桥接起来

基本信息

  • 批准号:
    10640424
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-02-01 至 2027-01-31
  • 项目状态:
    未结题

项目摘要

Advancements in neurotechnology are shaping the future of medical care for those suffering from neurological illness, disease, and injury. Unfortunately, it can take decades to bring such advances from the benchtop to the bedside in service of our Veterans. The development, evaluation, optimization, and deployment of each subcomponent of a medical device is complex, and combinations of technologies are required to address the complex needs of Veterans with, for example, traumatic brain and spinal cord injuries. In fact, the last major neurotechnology translational success was arguably the deep brain stimulator (DBS) developed in the 1980’s, delivering electrical neuromodulation to the brain to reduce Essential and Parkinson’s Disease-related tremor, but were not approved by the Food and Drug Administration until 2002. While impressive technologies are on the horizon, including those supported by the Department of Veterans Affairs, the time, money, and scientific divide between benchtop successes and bedside therapeutic application is exceptionally vast. Bioelectronics are hyped as an alternative to drug interventions, but the reality is that the translation timelines for medical devices—and their success rates as therapeutic tools—mirror the slow and costly development of new pharmaceuticals rather than mirroring the lean, accelerated development of new electronics for the consumer market. This issue matters because the socioeconomic burden of neurological injury and disorders is significant. Spinal cord injuries (SCIs) alone are estimated to affect between 249,000 and 363,000 Americans (NSCISC), and roughly 42,000 people with SCIs are Veterans, an estimated $5M/patient over their lifetime in health care costs. Nearly half of all SCIs occur in people between the ages of 16 and 30, leaving many to live with the injuries for decades. The inefficiency of bringing new drugs to market is dubbed “Eroom’s” law, given the exponentially increasing cost of drug release—in contrast to Moore’s law, originally referring to the number of transistors on a microchip doubling every 2 years though the cost of computers is halved, but more generally illustrating the exponential growth for technologies over time. From a translational perspective, the efficiency of medical device innovation still has much more in common with pharmacological research and development (R&D) than it does with Moore’s law and consumer electronics. We propose the development of a hardware and software accelerator platform (“cross-development”, or xDev) for electrophysiology research and neurotechnology creation. Development of this platform would enable new research into spinal cord stimulation for sensorimotor restoration in SCI, as well as for continued investigation of spinal electrophysiology in closed-loop devices for chronic pain. The new tool will be used to accelerate design, development and deployment of neurotechnology by smoothing the transition between design phases, allowing rapid redesign and re-verification of neurotechnology components. The xDev platform maximizes the ability of neurotechnology device developers to test their tools with versatile interfaces, algorithms, and underlying chipsets, improving compatibility, cross-functionality, and inspiring new collaborations between technology developers. Strategic platform organization protects neurotechnology developers’ intellectual property, while improving modularity with tools from other manufacturers. Leveraging the xDev platform, we will demonstrate a new neurotechnology enabling chronic recording of spinal electrophysiology and fill a neuroscientific knowledge gap, connecting the fields of Restorative Neurology and therapeutic spinal cord neuromodulation.
神经技术的进步正在塑造神经系统疾病患者医疗护理的未来

项目成果

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David Allenson Borton其他文献

David Allenson Borton的其他文献

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{{ truncateString('David Allenson Borton', 18)}}的其他基金

Bioengineering a cortical microtissue model to study human microglia in Alzheimer's disease
生物工程皮质微组织模型来研究阿尔茨海默病中的人类小胶质细胞
  • 批准号:
    10630949
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Bioengineering a cortical microtissue model to study human microglia in Alzheimer's disease
生物工程皮质微组织模型来研究阿尔茨海默病中的人类小胶质细胞
  • 批准号:
    10448954
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Spatiotemporal Coding in the Pain Circuit Along the Spine-brain Continuum
沿着脊柱-大脑连续体的疼痛回路的时空编码
  • 批准号:
    10205394
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
Accelerating Dissemination of Implantable Neurotechnology for Clinical Research
加速临床研究植入式神经技术的传播
  • 批准号:
    10470025
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Accelerating Dissemination of Implantable Neurotechnology for Clinical Research
加速临床研究植入式神经技术的传播
  • 批准号:
    10689290
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Accelerating Dissemination of Implantable Neurotechnology for Clinical Research
加速临床研究植入式神经技术的传播
  • 批准号:
    10238761
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Large Scale Cortical Laminar Recordings: Novel Instrumentation
大规模皮质层流记录:新颖的仪器
  • 批准号:
    10078368
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Spatiotemporal Coding in the Pain Circuit Along the Spine-brain Continuum
沿着脊柱-大脑连续体的疼痛回路的时空编码
  • 批准号:
    10305343
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
The Role of M1 Leg Area in Volitional and Stereotyped Control of the Lower Limb
M1 腿部区域在下肢意志和刻板控制中的作用
  • 批准号:
    10021472
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
Spatiotemporal Coding in the Pain Circuit Along the Spine-brain Continuum
沿着脊柱-大脑连续体的疼痛回路的时空编码
  • 批准号:
    10267899
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:

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