COOPERATIVE MULTICENTER NEONATAL DATA CENTER

描述（改编自申请人的描述）：三角研究 研究所（RTI）建议作为数据协调中心（DCC）， 合作多中心新生儿研究网络。 高级工作人员 为该网络提出的建议已指导数据协调中心， 二十五年来，已经完成或正在进行五项重大的 产妇/围产期/新生儿研究。 W博士肯尼斯·普尔 曾担任11个DCC重大项目的首席研究员。 在 特别是他一直是高频率的首席研究员 通气（HIFI）和呼吸窘迫综合征（RDS）研究， 阴道感染和早产（VIP）研究的共同研究者， NICHD早期儿童保育研究（SECC）和 DC倡议研究。 Dr. A. Vijaya Rao是一名拟议的共同研究者， 主要研究者DC倡议，是VIP的主要研究者 研究，并且是HIFI和RDS研究的共同研究者。 泰勒博士D. Hartwell是拟定的合作研究者，目前是主要研究者 对于SECC的DCC，这与网络的孕产妇非常相似 生活方式项目。 此外，普尔博士和拉奥博士以及一些建议 工作人员已经与四个当前的网络PI在HIFI和RDS上合作 问题研究 所有的工作人员都在DCC工作了很多年 项目包括产妇/围产期/新生儿研究。 顾问以及弗兰克·波特·格雷厄姆·蔡尔德 发展中心（FPG）包括儿童发展，纵向 数据分析、心理测量学和卫生经济学。 RTI工作人员目前 在其他项目中与所有这些合作。 RTI在罗克维尔设有办事处， NICHD将安排两名全职网络协调员， 新生儿研究和一名秘书，以促进协调， 与NICHD工作人员就该项目进行沟通。 RTI计划采取 该网络在统计设计领域的领导作用， 分析、数据收集程序、数据管理和处理， 质量控制、随机化、研究后勤、DCC之间的转换， 网络通讯，以及追踪毒品供应和标本。 他们将 使用最先进的数据收集、处理和管理方法， 包括计算机辅助数据收集方法、电子数据 转让，一个网站，并与研究合作者的互联网链接。 RTI的矩阵式管理结构，可根据具体情况分配工作人员 为几个项目提供了相当大的灵活性， 在需求高峰期为项目提供额外资源。 研究所 协调中心工作人员与研究中心PI的合作记录令人印象深刻 和统计人员编写出版手稿。

DESCRIPTION (Adapted from the applicant's description): Research Triangle Institute (RTI) proposes to serve as the Data Coordinating Center (DCC) for the Cooperative Multicenter Neonatal Research Network. The senior staff proposed for this Network have directed data coordinating centers for over twenty-five years and have completed or are now conducting five major studies in maternal/perinatal/neonatal research. Dr. W. Kenneth Poole, the proposed Principal Investigator, has served on 11 major DCC projects. In particular he has been the Principal Investigator of the High Frequency Ventilation (HIFI) and Respiratory Distress Syndrome (RDS) studies, Co-Investigator of the Vaginal Infection & Prematurity (VIP) study and is senior statistician on NICHD'S Study of Early Child Care (SECC) and of the DC Initiative studies. Dr. A. Vijaya Rao, a proposed Co-investigator, is Principal Investigator DC Initiative, was Principal Investigator of the VIP study, and was Co-investigator on the HIFI and RDS studies. Dr. Tyler D. Hartwell, a proposed Co-investigator, is currently Principal Investigator for the DCC for the SECC which is very similar to the Network's Maternal Lifestyles (MLS) project. Also, Drs. Poole and Rao and some of the proposed staff have worked with four of the current Network PIs on the HIFI and RDS studies. All of the staff have worked together for many years on DCC projects including the studies in maternal/perinatal/neonatal research. Consultants proposed as well as staff from the Frank Porter Graham Child Development Center (FPG) include experts in child development, longitudinal data analysis, psychometrics, and health economics. RTI staff are currently working with all of these on other projects. RTI has Rockville offices near NICHD and will place two full time Network coordinators with experience in neonatal studies and a secretary to facilitate coordination and communication with NICHD staff on this project. RTI plans to take a leadership role for the Network in the areas of statistical design and analysis, data collection procedures, data management, and processing, quality control, randomization, study logistics, transition between DCCs, Network communications, and tracking drug supplies and specimens. They will use state-of-the-art methods of data collection, processing, and management, including computer assisted data collection methods, electronic data transfer, a Web site, and Internet linkages with the study collaborators. RTI's matrix management structure, whereby individual staff may be assigned to several projects, provides considerable flexibility in allocating additional resources to projects at times of peak needs. Institute coordinating center staff have an impressive record working with site PIs and statisticians in the development of manuscripts for publication.