Development of specific inhibitors of Porphyromonas gingivalis gingipains based on their cognate propeptides

基于牙龈卟啉单胞菌前肽的特异性抑制剂的开发

• 批准号: nhmrc : 1081252
• 负责人: Dr Laila Huq
• 金额: $ 40.85万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-specific-inhibitors-cognate-propeptides/518795
• 关键词: Development; specific; inhibitors; Porphyromonas; gingivalis

Gum disease (periodontitis) is an inflammatory disease caused by bacterial pathogens that is the major cause of tooth loss in adults. It is also associated with systemic diseases such as cardiovascular disease. In this study we will develop novel peptide-based therapeutics to inhibit the proteases that enable these bacteria to cause disease.

牙龈疾病（牙周炎）是一种由细菌病原体引起的炎症性疾病，是成人牙齿脱落的主要原因。它还与心血管疾病等全身性疾病有关。在这项研究中，我们将开发新的基于肽的疗法来抑制使这些细菌引起疾病的蛋白酶。