FLAVONOIDS AND CARDIOVASCULAR DISEASE

黄酮类化合物与心血管疾病

• 批准号: 6193499
• 负责人: HOWARD D SESSO
• 金额: $ 6.35万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6193499
• 关键词: antioxidants; cardiovascular disorder epidemiology; cardiovascular disorder prevention; clinical research; dietary constituent; flavonoids; human data; nutrition related tag

DESCRIPTION (Adapted from the applicant's abstract) Basic science, clinical observation, and epidemiologic studies have all contributed to an emerging body of evidence on the potential role of flavonoids, a group of polyphenolic compounds with antioxidant properties, in the prevention of CVD. However, the few existing studies on flavonoids or its food sources have provided inconsistent results, usually focusing on the primary prevention of coronary heart disease mortality. Therefore, the investigators propose to examine whether flavonoid intake is associated with the risk of incident CVD, and whether specific food sources of flavonoids--including tea, onions, apples, red wine, and other foods--are associated with the risk of incident CVD. The investigators will process and analyze previously collected data of 39,876 middle-aged and older women free of CVD; the Women's Antioxidant Cardiovascular Study (WACS), a prospective study of 8,171 middle-aged and older women with pre-existing CVD or >3 coronary risk factors; the Normative Aging Study (NAS), a prospective study of 2,280 middle-aged and older men; and the Boston Area Health Study (BAHS), a case-control study of first nonfatal Ml in men and women aged <76 years. Using data from semiquantitative food frequency questionnaires administered in each study, the investigators will determine individual intake of flavonoids and its food sources. Unlike previous studies, they will examine flavonoids in relation to both the primary and secondary prevention of incident CVD, consisting of confirmed cases of nonfatal Ml, nonfatal stroke, revascularization procedures, and CVD death. They will have 80% power to detect a significant trend across quartiles with a 32% reduction in CVD risk in the highest quartile for WHS, 31% reduction for WACS, 41% reduction for NAS, and 35% reduction for BAHS. In light of increasing media attention and public awareness on the promise of flavonoids in CVD prevention, this proposal to analyze these four existing databases will provide important new data on flavonoids and its food sources in both the primary and secondary prevention of incident CVD.

描述 （改编自申请人的摘要）基础科学、临床观察、 和流行病学研究都促成了越来越多的证据 关于类黄酮的潜在作用，类黄酮是一组多酚化合物，具有 抗氧化特性，预防CVD。 然而，现有的少数 对类黄酮或其食物来源的研究提供了不一致的结果， 通常注重冠心病的一级预防 死亡。 因此，研究人员建议检查类黄酮是否 摄入量与发生心血管疾病的风险相关，并且特定食物是否 黄酮类化合物的来源——包括茶、洋葱、苹果、红酒和其他 食物——与心血管疾病的风险相关。 调查人员将 处理和分析之前收集的 39,876 名中老年人数据 没有心血管疾病的女性；女性抗氧化心血管研究 (WACS) 对 8,171 名患有 CVD 的中老年女性进行的前瞻性研究 或 >3 个冠状动脉危险因素；规范老龄化研究（NAS）是一项前瞻性研究 对 2,280 名中老年男性的研究；和波士顿地区健康研究 (BAHS)，一项针对年龄 <76 岁的男性和女性首次非致命性ML的病例对照研究 年。 使用半定量食物频率调查问卷的数据 在每项研究中，研究人员将确定个人摄入量 类黄酮及其食物来源。 与之前的研究不同，他们将 检查类黄酮与一级和二级预防的关系 CVD 事件，包括已确诊的非致命性 Ml、非致命性中风病例、 血运重建手术和 CVD 死亡。 他们将拥有80%的权力 检测四分位数的显着趋势，CVD 风险降低 32% 在 WHS 的最高四分位数中，WACS 减少了 31%，WACS 减少了 41% NAS，BAHS 减少 35%。 鉴于媒体关注度的不断提高和 公众对类黄酮在预防心血管疾病方面的承诺的认识，该提案 分析这四个现有数据库将提供重要的新数据 类黄酮及其食物来源在一级和二级预防中的作用 CVD事件。