MAP THE SUSCEPTIBILITY GENE IN CHINESE SLE SIBPAIRS

绘制中国 SLE SIBP 对的易感基因图谱

• 批准号: 6188692
• 负责人: BETTY P TSAO
• 金额: $ 3.15万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6188692
• 关键词: Chinese; alleles; clinical research; family genetics; genetic markers; genetic polymorphism; genotype; human subject; linkage mapping; siblings; systemic lupus erythematosus

The parent project for this FIRCA application is an R01 grant to determine whether five candidate human chromosomal regions confer major susceptibility to SLE. The candidate regions were identified by mouse homologues, and will be studied by linkage and association methods in 300 multiplex families ascertained through UCLA clinics, which was intended to be an ethnically heterogeneous mix, since one of the hypotheses is that SLE-predisposing genes will be conserved across ethnic groups. This group has reported evidence for linkage of SLE to markers on chromosome 1q41-q42, and nonparametric allele sharing methods among affected sib pairs seemed to suggest that the greatest proportion of allele sharing occurred in the Asian subset, which included 10 sib pairs of southern Han Chinese descent. Wishing to extend upon this finding in an ethnically homogeneous subset, Dr. Tsao proposes a collaboration with investigators in the Department of Rheumatology at Ren Ji Hospital in Shanghai, China. The goals of the FIRCA grant are to identify and enroll 100 Chinese SLE-affected sibpair families, to genotype blood samples or buccal swabs with markers densely located in the candidate region, and to analyze the data using nonparametric linkage and association methods.

此FIRCA应用程序的父项目是R01授予 确定人类染色体的五个候选区域是否授予主要 对系统性红斑狼疮易感性。用小鼠识别候选区域 同源物，并将通过链接和关联方法在 通过加州大学洛杉矶分校的诊所确认了300个多用途家庭，这是 打算成为一个种族混杂的群体，因为其中一个 假设系统性红斑狼疮的易感基因将在 种族群体。该小组已经报告了SLE与 染色体1q41-q42上的标记和非参数等位基因共享方法 在受影响的同胞对中，似乎表明最大比例的 的等位基因共享发生在包括10个同胞的亚洲亚群中 一对南方汉人后裔。 希望在种族同质的子集中扩展这一发现， 曹博士建议与该部门的调查人员合作 上海仁济医院风湿科主任中国说。世界银行的目标是 FIRCA赠款将识别和登记100对受SLE影响的中国同胞 对血样或口腔拭子进行密集的标记基因分型 位于候选区域中，并使用 非参数链接和关联方法。