HYBRID, FLAT-PANEL, ACTIVE MATRIX MAMMOGRAPHIC IMAGER
混合、平板、有源矩阵乳腺X线成像仪
基本信息
- 批准号:6150266
- 负责人:
- 金额:$ 78.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-03-05 至 2002-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Since their initial development in the late 1980's, active-matrix, flat-
panel imagers (AMFPIs) have developed at an exponential rate with
devices expected soon to reach 30x40 cm2, to exceed 3x10/6 pixels, and
with pixel-to-pixel pitches as low as 100 microm. Given the high degree
of interest in developing improved means to digitally acquire breast
images, it is natural to pose the question: "Is it feasible to develop
a practical, full-field, high-resolution (i.e. 50 microm pixel pitch or
finer) AMFPI for mammography?" The extrapolation of the design of
present AMFPIs (based on either the direct or indirect detection
approaches) to 50 microm pitchers of finer is not possible due to a
variety of severe difficulties that arise below 100 microm.
Consequently, this grant application proposes to test the hypothesis
that, through the introduction of fundamental innovations to flat-panel
array design, full-field (i.e. 24x30 cm2) direct and indirect detection
AMFPIs with spatial resolutions consistent with the rigorous demands of
the mammographic application are feasible. an ambitious program of
research is proposed involving the iterative design, fabrication, and
evaluation (including measurements of observer independent performance
variables such as MTF(f), NPS(f) and DQE(f) as well as theoretical
modeling based on a cascaded systems approach) of a series of small
(approximately 5x6 cm2 with 50 microm to 100 microm pixel pitch) and
full-field (24x30 cm2 with 50 mcirom pixel pitch) prototype imagers. A
variety of innovations, which will circumvent present limitations in
AMFPI design, will be developed and investigated. The successful
conclusion of the proposed research will facilitate the creation of new
digital mammographic x-ray imaging technologies based on both direct and
indirect detection. These technologies will offer 50 microm pixel
resolution in the near term, and if required, even finer pixel
resolution int he future. Such AMFPIs would offer the promise of digital
imaging with large dynamic range allowing wider exposure ranges and
significantly reducing the need for retakes compared to screen-film
systems. these imagers would be less costly to build them present
AMFPIs, and could be packaged with a profile approaching that of a film
cassette. They would potentially offer a detective quantum efficiency
significantly superior to current screen-film systems allowing for
enhanced image quality and/or a reduction in patient exposure and
ultimately could serve as a highly useful tool in the early diagnosis
of breast cancer.
自20世纪80年代末首次开发以来,有源矩阵,平板-
平板成像仪(AMFPI)以指数速度发展,
设备预计很快将达到30 x40 cm 2,超过3x 10/6像素,
像素间距低至100微米。考虑到
感兴趣的是开发改进的数字获取乳房的方法,
图像,很自然地提出这样的问题:“发展是否可行?
一种实用的、全场的、高分辨率的(即50微米像素间距或
AMFPI用于乳房X光检查?“外推的设计,
目前AMFPI(基于直接或间接检测
方法)到50 microm投手的罚款是不可能的,由于一个
100微米以下出现的各种严重困难。
因此,这项拨款申请旨在检验这一假设
通过对平板电脑的基本创新,
阵列设计,全视野(即24 x30 cm 2)直接和间接检测
AMFPI的空间分辨率符合
乳房X线摄影应用是可行的。一项雄心勃勃的计划,
研究提出了涉及迭代设计,制造,
评估(包括独立于观察员的绩效测量
MTF(f)、DQE(f)等变量以及理论值
模型的基础上级联系统的方法)的一系列小
(约5x 6 cm 2,像素间距为50微米至100微米),
全视场(24 × 30 cm 2,50 MCIROM像素间距)原型成像器。一
各种创新,这将规避目前的限制,
AMFPI设计,将被开发和研究。成功
建议的研究结论将有助于创造新的
数字乳腺X射线成像技术,
间接检测这些技术将提供50微米像素
分辨率在短期内,如果需要,甚至更精细的像素
未来的决心。这种AMFPI将提供数字化的承诺,
具有大动态范围的成像,允许更宽的曝光范围,
与屏幕电影相比,
系统.这些成像器的成本会更低
AMFPI,并可以与接近电影的轮廓包装在一起
盒式磁带。它们有可能提供一种量子效率探测器
显著上级当前的屏幕-胶片系统,
增强图像质量和/或减少患者暴露,以及
最终可以作为一个非常有用的工具,在早期诊断
乳腺癌
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LARRY E ANTONUK其他文献
LARRY E ANTONUK的其他文献
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{{ truncateString('LARRY E ANTONUK', 18)}}的其他基金
Development of a High Sensitivity, X-ray Detector Technology Based on Polycrystalline Mercuric Iodide for Volumetric Breast Imaging
开发基于多晶碘化汞的高灵敏度 X 射线探测器技术,用于体积乳腺成像
- 批准号:
9236895 - 财政年份:2016
- 资助金额:
$ 78.41万 - 项目类别:
An Advanced Technology Flat-Panel Imager for Fluoroscopy
用于荧光检查的先进技术平板成像仪
- 批准号:
8249853 - 财政年份:2002
- 资助金额:
$ 78.41万 - 项目类别:
An Advanced Technology Flat-Panel Imager for Fluoroscopy
用于荧光检查的先进技术平板成像仪
- 批准号:
6548375 - 财政年份:2002
- 资助金额:
$ 78.41万 - 项目类别:
An Advanced Technology Flat-Panel Imager for Fluoroscopy
用于荧光检查的先进技术平板成像仪
- 批准号:
7656521 - 财政年份:2002
- 资助金额:
$ 78.41万 - 项目类别:
An Advanced Technology Flat-Panel Imager for Fluoroscopy
用于荧光检查的先进技术平板成像仪
- 批准号:
7810684 - 财政年份:2002
- 资助金额:
$ 78.41万 - 项目类别:
An Advanced Technology Flat-Panel Imager for Fluoroscopy
用于荧光检查的先进技术平板成像仪
- 批准号:
8054213 - 财政年份:2002
- 资助金额:
$ 78.41万 - 项目类别:
An Advanced Technology Flat-Panel Imager for Fluoroscopy
用于荧光检查的先进技术平板成像仪
- 批准号:
6775698 - 财政年份:2002
- 资助金额:
$ 78.41万 - 项目类别:
An Advanced Technology Flat-Panel Imager for Fluoroscopy
用于荧光检查的先进技术平板成像仪
- 批准号:
6619730 - 财政年份:2002
- 资助金额:
$ 78.41万 - 项目类别:
HYBRID, FLAT-PANEL, ACTIVE MATRIX MAMMOGRAPHIC IMAGER
混合、平板、有源矩阵乳腺X线成像仪
- 批准号:
2452354 - 财政年份:1998
- 资助金额:
$ 78.41万 - 项目类别:
HYBRID, FLAT-PANEL, ACTIVE MATRIX MAMMOGRAPHIC IMAGER
混合、平板、有源矩阵乳腺X线成像仪
- 批准号:
2871989 - 财政年份:1998
- 资助金额:
$ 78.41万 - 项目类别: