Pain After Covid-Multidisciplinary Action Network

新冠疫情后的痛苦-多学科行动网络

• 批准号: MR/Y03371X/1
• 负责人: Sam Eldabe
• 金额: $ 5.22万
• 依托单位: South Tees Hospitals NHS Foundation Trust
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FY03371X%2F1
• 关键词: Pain; After; Covid; Multidisciplinary; Action

Over 200 million patients (pts) worldwide have fatigue, widespread muscle pain, joint andchest pain due to COIVD-19 infection. Little is known on onset, pathophysiology and clinicalhistory of chronic pain post-COVID, leaving doctors at loss when it comes to specificallyidentify and diagnose pts and prescribe most effective treatments. To advance knowledgeon post-COVID chronic pain, to discuss current clinical gaps, develop potential solutions forthese pressing issues we propose a multidisciplinary consortium:-clinicians working with long COVID pts and specific knowledge of chronic post-COVID painsyndrome.-clinical experts in chronic pain syndromes in specific settings: paediatric and chronicpostoperative pain, chronic pain neuromodulation;-basic scientists applying genomics for a better understanding of pain pathophysiology andusing glycomics to predict long COVID and stratify the risk of pts to develop long COVID associatedsevere illness;-translational scientists, pharmacology and nanomedicine experts for development of newnanotherapies to tackle chronic pain, inflammation and immune activation;-startups, established biotech companies interested in development of new therapeutic toolsfor pain, incl.an international CDMO involved in industrialization ofpharmaceutical/nutraceutical products, scientific associations (Redirect) for spreading theculture of rational approach to chronic postoperative pain and inflammatory chronic pain.

全球超过2亿患者因covid -19感染而出现疲劳、广泛的肌肉疼痛、关节和胸痛。人们对新冠肺炎后慢性疼痛的发病、病理生理和临床病史知之甚少，这让医生在具体识别和诊断患者并开出最有效的治疗方案时无所适从。为了提高对COVID - 19后慢性疼痛的认识，讨论当前的临床差距，为这些紧迫问题制定潜在的解决方案，我们提出了一个多学科联盟：具有长期COVID - 19患者和COVID - 19后慢性疼痛综合征特定知识的临床医生。-特殊情况下慢性疼痛综合征的临床专家：儿科和慢性术后疼痛，慢性疼痛神经调节；-基础科学家应用基因组学来更好地理解疼痛病理生理学，并使用糖组学来预测长期COVID，并对患者发展长期COVID相关严重疾病的风险进行分层；-转化科学家、药理学和纳米医学专家，为解决慢性疼痛、炎症和免疫激活开发新的纳米疗法；-初创公司，对开发新的疼痛治疗工具感兴趣的成熟生物技术公司，包括参与药物/营养产品产业化的国际CDMO，传播合理方法治疗慢性术后疼痛和炎症性慢性疼痛的科学协会。