Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases
系统性自身免疫性风湿病患者 COVID-19 后的免疫学和临床后遗症
基本信息
- 批准号:10583192
- 负责人:
- 金额:$ 78.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-02-01 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAcuteAffectAmericanAntibodiesAntibody ResponseAutoantibodiesAutoimmunityB-LymphocytesBiophysicsCOVID-19COVID-19 impactCOVID-19 pandemicCOVID-19 pathogenesisCOVID-19 riskCOVID-19 survivorsCharacteristicsChestChest imagingClinicalCommunity HospitalsComplicationCoronavirusDataDiagnosticDiseaseDisease OutbreaksDoseEffectivenessEtiologyEvolutionFibrosisGeneral HospitalsGeneral PopulationHigh Resolution Computed TomographyHospitalsHumoral ImmunitiesImageImmuneImmune responseImmunologicsImmunomodulatorsImmunosuppressive AgentsInfectionKnowledgeLeadMassachusettsMeasuresMedicineNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesObservational StudyOutcomePatientsPhenotypePost-Acute Sequelae of SARS-CoV-2 InfectionPredispositionPrincipal InvestigatorProspective cohortPulmonary FibrosisRNA vaccineRecommendationResearchRespiratory Signs and SymptomsRetrospective cohort studyRheumatoid ArthritisRiskSARS-CoV-2 infectionSamplingSourceSymptomsSystemSystemic Lupus ErythematosusTNF geneVaccinatedVaccinationVaccinesVariantViralVirus DiseasesVirus SheddingVulnerable PopulationsWomanWorkautoimmune rheumatologic diseasebreakthrough infectioncohortcoronavirus diseasefibrotic lung diseasehigh riskinhibitormedical schoolspandemic diseaseparticipant enrollmentpathogenpost-COVID-19professorprospectiveprototypepublic health relevancerespiratoryresponserheumatologistrituximabtertiary caretherapy resistantvaccine immunogenicityvirology
项目摘要
PROJECT SUMMARY
The 5 million Americans living with systemic autoimmune rheumatic diseases (SARDs), such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), are at increased risk of poor COVID-19 outcomes. SARO treatment with immunomodulators may lead to blunted and dysregulated immune responses to vaccination and infection. SARDs are characterized by a predisposition to autoantibody formation and fibrosis. These factors may place SARDs at risk for poor short-term outcomes (e.g., breakthrough infection, prolonged viral shedding) and post-acute sequelae of COVID-19 (PASC), characterized by prolonged COVID-19 symptoms (>/=28 days). PASC is of high clinical and
项目概要
500 万美国人患有系统性自身免疫性风湿病 (SARD),例如类风湿性关节炎 (RA) 和系统性红斑狼疮 (SLE),其 COVID-19 预后不良的风险增加。使用免疫调节剂进行 SARO 治疗可能会导致对疫苗接种和感染的免疫反应减弱和失调。 SARD 的特点是易于形成自身抗体和纤维化。这些因素可能使 SARD 面临短期结果不佳(例如突破性感染、长时间病毒脱落)和 COVID-19 急性后遗症(PASC)的风险,其特征是长期 COVID-19 症状(>/=28 天)。 PASC具有较高的临床和
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey Andrew Sparks其他文献
Jeffrey Andrew Sparks的其他文献
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{{ truncateString('Jeffrey Andrew Sparks', 18)}}的其他基金
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
类风湿关节炎相关自身抗体、关节炎症和 RA 相关间质性肺病
- 批准号:
10491725 - 财政年份:2021
- 资助金额:
$ 78.25万 - 项目类别:
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
类风湿关节炎相关自身抗体、关节炎症和 RA 相关间质性肺病
- 批准号:
10647761 - 财政年份:2021
- 资助金额:
$ 78.25万 - 项目类别:
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease
类风湿关节炎相关自身抗体、关节炎症和 RA 相关间质性肺病
- 批准号:
10207955 - 财政年份:2021
- 资助金额:
$ 78.25万 - 项目类别:
Respiratory Diseases, Genetics, and Rheumatoid Arthritis Risk
呼吸系统疾病、遗传学和类风湿关节炎风险
- 批准号:
9810123 - 财政年份:2019
- 资助金额:
$ 78.25万 - 项目类别:
Rheumatoid Arthritis and Respiratory Outcomes in Prospective Cohorts
未来队列中的类风湿关节炎和呼吸系统结局
- 批准号:
9262145 - 财政年份:2016
- 资助金额:
$ 78.25万 - 项目类别:
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