MICROWAVE THERMOKERATOPLASTY WITH SURFACE COOLING

表面冷却微波热角膜成形术

• 批准号: 2882907
• 负责人: B STUART TREMBLY
• 金额: $ 17.81万
• 依托单位: MGR TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2882907
• 关键词: biomedical equipment development; cats; corneal epithelium; eye refraction disorder; histology; hyperthermia therapy; keratoplasty; method development; microwave radiation; myopia; phantom model; surface property

DESCRIPTION (Adapted from Applicant's Abstract): The objectives of this research are to design and construct a clinical version of a system for microwave thermokeratoplasty with surface cooling for correction of myopia, and to assess the refractive effects of such treatments in animal subjects after one year. Specifically, the applicants proposed to improve the system tested in Phase I of this project by adding features that reduce the technical skill required to treat. Furthermore, the proposed to test the hypothesis that two specified diameters of treated ring in the cornea would produce stable, specified changes in refraction after one year. Microwave thermokeratoplasty shrinks the stromal layer of the cornea in a ring around the optical zone through absorption of microwave energy in order to change the curvature of the cornea and hence its dioptric power. The proposed system incorporates surface cooling to protect the epithelium from elevated temperatures. Consequently, there is no need to wait for re-epithelialization after treatment, as is the case with current techniques, such as radial keratotomy and photorefractive keratectomy. There is significant commercial potential for this device, since roughly 50% of the U.S. population requires correction to vision. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：本项目的目标 研究的目的是设计和构建一个临床版本的系统 微波热角膜移植术与表面冷却矫正 近视，并评估此类治疗的屈光效果 一年后的动物受试者。 具体而言，申请人提出 通过添加来改进该项目第一阶段测试的系统 减少治疗所需技术技能的功能。 此外，建议检验两个指定的假设 角膜中经过处理的环的直径将产生稳定的、指定的 一年后屈光度的变化。 微波热角膜移植术 使角膜基质层收缩，形成围绕光学镜片的环 通过吸收微波能量来改变区域 角膜曲率及其屈光力。 拟议的 系统采用表面冷却来保护上皮免受 温度升高。 因此，无需等待 治疗后的上皮再形成，与目前的情况一样 技术，例如放射状角膜切开术和屈光性角膜切除术。 该设备具有巨大的商业潜力，因为大约 50% 的美国人需要矫正视力。 拟议的商业应用：不可用