DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS

滥用药物、奖励比较和丘脑

• 批准号: 6196943
• 负责人: Patricia Sue Grigson
• 金额: $ 26.93万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6196943
• 关键词: behavioral /social science research tag; behavioral habituation /sensitization; cocaine; conditioning; dosage; drug abuse; drug addiction; electrophysiology; heroin; laboratory rat; morphine; neuroanatomy; operant conditionings; reinforcer; repression; self medication; sensory cortex; stimulus /response; substance abuse related behavior; sucrose; thalamus

DESCRIPTION: (Adapted from the Investigator's Abstract) Rats will decrease intake of a saccharin conditioned stimulus (CS) following pairing with an illness-inducing agent such as LiCl, a preferred high concentration of sucrose, or a drug of abuse such as morphine or cocaine. The suppressive effects of the illness-inducing agent are clear evidence for aversive conditioning and are referred to as conditioned taste aversions. The suppressive effects of the rewarding sucrose solution reflect appetitive conditioning and are referred to as anticipatory contrast effects because the saccharin CS is thought to be devalued as it comes to predict the future availability of the preferred sucrose reward. Finally, despite the well-known rewarding properties of drugs of abuse, the suppressive effects of these drugs have been viewed as conditioned taste aversions for over 25 years. We have, however, recently posed an alternative interpretation that eliminates this apparent paradox. Specifically, we have suggested that rats suppress intake of a saccharin CS following saccharin-morphine pairings, for example, because the saccharin CS is devalued as it comes to predict the future availability of the highly rewarding drug of abuse. Thus, we postulate that the same rewarding properties that increase self-administration of the drug also serve to devalue the gustatory cue that predicts its availability. The results from the Preliminary Studies support this novel hypothesis by showing that the suppressive effects of drugs of abuse and sucrose, but not LiCl, are influenced by deprivation state of the animal, the caloric value of the gustatory CS, the strain of the rat, and lesions of the gustatory thalamus. The objective of this proposal is to use a lesion-behavioral analysis to (I) evaluate the relative contribution of the gustatory thalamus and its terminal projection region, the gustatory cortex, (II) identify the parametric constraints on the impairment, and (III), given that rats will suppress saccharin intake when paired with iv cocaine (Preliminary Study #5), examine the nature of the lesion-induced deficit using the self-administration task.

描述：（根据调查人员的摘要改编）大鼠会减少 摄入糖精条件刺激（CS）之后 诱发疾病的剂，例如LICL，首选高浓度的蔗糖， 或滥用药物，例如吗啡或可卡因。抑制作用的效果 诱发疾病的剂是厌恶调节的明确证据，并且 称为条件味道厌恶。抑制作用的效果 奖励蔗糖解决方案反映了食欲的条件，并提及 作为预期的对比效果，因为糖精CS被认为是 贬值是为了预测首选的未来可用性 蔗糖奖励。最后，尽管毒品具有众所周知的奖励特性 在虐待中，这些药物的抑制作用被视为 有条件的口味厌恶已有25年了。但是，我们最近提出了 消除了这种明显悖论的另一种解释。 具体而言，我们建议大鼠抑制糖精CS的摄入量 例如，以下糖精蛋白 - 多电配对，因为糖精CS为 贬值是为了预测高度有益的未来可用性 滥用药物。因此，我们假设具有相同的奖励性能 增加药物的自我给药也有助于贬值 预测其可用性的提示。初步研究的结果 通过表明药物的抑制作用来支持这一新的假设 滥用和蔗糖而不是licl，受到剥夺状态的影响 动物，味觉CS的热量值，大鼠的应变和 味觉丘脑的病变。该提议的目的是使用 病变 - 行为分析（i）评估的相对贡献 味性丘脑及其末端投影区，味皮层， （ii）确定损伤上的参数约束，（iii）给定 当与静脉可卡因配对时，大鼠会抑制糖精的摄入量 （初步研究＃5），检查使用病变引起的缺陷的性质 自我管理任务。