An invitro model system to assess kidney pathogen interations determining outcome of Candida Albicans infections

评估肾脏病原体相互作用的体外模型系统，确定白色念珠菌感染的结果

• 批准号: NC/K50046X/1
• 金额: $ 15.29万
• 依托单位: University of Aberdeen
• 依托单位国家: 英国
• 项目类别: Training Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NC%2FK50046X%2F1
• 关键词: invitro; model; system; assess; kidney

The mouse intravenous challenge model is currently used to assay the virulence of Candida albicans strains. The main measures of virulence used are time to death or fungal burden in the tissues of mice killed at specific time points post-infection. The aim of this project is to devlop an in vitro virulence model using primary kidney cells or established cell lines. The new in vitro model will be used to evaluate the early stages of systemic infection in the kidneys, potentially replacing the use of mice in these studies.

小鼠静脉内激发模型目前用于测定白色念珠菌菌株的毒力。使用的毒力的主要测量是死亡时间或在感染后特定时间点杀死的小鼠组织中的真菌负荷。本研究的目的是利用原代肾细胞或已建立的细胞系建立体外毒力模型。新的体外模型将用于评估肾脏系统性感染的早期阶段，可能取代这些研究中使用的小鼠。