BIOMARKERS OF BENZENE EXPOSURE IN INTER CITY RESIDENTS

城际居民苯暴露的生物标志物

• 批准号: 6178526
• 负责人: VIRGINIA M WEAVER
• 金额: $ 9.27万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6178526
• 关键词: age difference; benzene; biomarker; child (0-11); clinical chemistry; clinical research; disease /disorder proneness /risk; environmental toxicology; epidemiology; human subject; nicotine; parent offspring interaction; preschool child (1-5); racial /ethnic difference; toxin metabolism; urban poverty area

DESCRIPTION: (Adapted from the Investigator's Abstract) Environmental exposure to the human carcinogen, benzene, is an important public health concern because of its prevalence, particularly in cities. Further research is needed to identify and protect groups and individuals at increased risk for adverse health effects from benzene exposure. The incorporation of biomarkers would substantially strengthen such research by providing information on individual variation in absorption and metabolism. This variation is an essential factor in the markedly different human susceptibility for toxic outcomes at similar exposure levels. This group recently completed a pilot study which used biomarkers to explore environmental benzene exposure in an urban area. They measured trans, trans-muconic acid (ttMA), an aliphatic metabolite of benzene, and cotinine [to assess the benzene source - environmental tobacco smoke (ETS)], in the urine of 79 children who were already overexposed to one urban toxicant, lead. They measured ttMA in more than 70% of these children and found several unexpectedly high values. Cotinine levels were also strikingly elevated with 79.5% over 30 ng/mg creatinine, a level commonly associated with household exposure. These results suggest that they have identified a group at high risk for environmental benzene exposure. Two studies are proposed for further investigation of these findings. The first will determine whether the benzene biomarkers used adequately measure internal dose in environmental exposure. This will be accomplished by comparing the established exposure measurement, personal air benzene, with two biomarkers, ttMA and S-phenylmercapturic acid (S-PMA), in pre-school inner-city children and their mothers. These data will also be used to determine if age-related or ethnic differences in benzene metabolism exist. A second study, in a subset of mother-child pairs from the initial investigation, will include the above measures, along with the addition of breath benzene and more frequent biomarker assessments over the study day. Such data will be useful for comparison with animal and in vitro work to facilitate extrapolation in risk assessment. These studies provide the basis for a research agenda aimed at identifying and improving protection of susceptible groups exposed to environmental toxicants.

描述：（改编自研究者摘要）环境 暴露于人类致癌物苯是一个重要的公共健康问题， 这是一个令人担忧的问题，因为它的流行，特别是在城市。 进一步 需要进行研究，以确定和保护群体和个人， 苯暴露对健康产生不利影响的风险增加。 的 生物标志物的加入将大大加强这类研究 通过提供关于吸收的个体差异的信息， 新陈代谢. 这种变化是一个重要因素， 在相似暴露下，不同的人类对毒性结果的敏感性 程度. 该小组最近完成了一项试点研究， 生物标志物，探索在城市地区的环境苯暴露。 他们测量了反式，反式粘康酸（ttMA），一种脂肪族代谢物 苯和可替宁[以评估苯的来源-环境 烟草烟雾（ETS）]，在79名儿童的尿液中， 过度暴露于一种城市毒物铅中 他们测量了ttMA， 超过70%的儿童，并发现了几个意想不到的高值。 可替宁水平也显著升高，79.5%超过30 ng/mg 肌酐，这一水平通常与家庭接触有关。 这些 结果表明，他们已经确定了一个患有高风险的群体 环境苯暴露 建议进一步开展两项研究 调查这些发现。 第一个将决定 苯生物标志物用于充分测量体内剂量， 环境暴露。 这将通过比较 建立接触测量，个人空气苯，与两个 生物标志物，ttMA和S-苯巯基尿酸（S-PMA），在学龄前 贫民区的孩子和他们的母亲 这些数据还将用于 确定苯代谢是否存在年龄相关或种族差异 存在. 第二项研究，在一个母子配对的子集中， 初步调查，将包括上述措施，连同沿着 增加呼吸苯和更频繁的生物标志物评估， 学习日。 这样的数据将有助于与动物和 体外工作，以便利风险评估中的外推。 这些 研究为旨在确定和 加强对易受环境影响群体的保护 有毒物质