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VARIOUS CHEMOPREVENTIVE AGENTS EFFECTS

VARIOUS CHEMOPREVENTIVE AGENTS EFFECTS
各种化学预防剂的作用
批准号：
2600142
负责人：
Clinton Julian Grubbs
金额：
$32.99万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
未结题
起止时间：
1997-06-30 至
来源：
https://reporter.nih.gov/project-details/2600142
关键词：
aromatase breast neoplasms cancer prevention carcinogenesis inhibitor cell growth regulation chemoprevention disease /disorder model drug screening /evaluation histopathology laboratory rat methylnitrosourea oxidoreductase inhibitor

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英文摘要
The objective of this workstatement is to investigate the efficacy of a variety of potential chemopreventive agents in that MNU-induced rat mammary tumor model. This model which entails injection of MNU into 50 day old rats results in tumors with many of the same properties (histopathologic, endocrinologic, response to known therapeutic and chemopreventive agents) that are typical of the human disease. This model will e used to examine a number of potential chemopreventive agents including aromatase inhibitors, differentiating agents, specific inhibitors of prostaglandin synthesis, etc. Agents which are highly effective in these models will be further investigated with respect to their biologic and toxicologic properties and advanced into clinical testing if these initial results appear promising.
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