ACTIVATION AND REPRESSION OF TRANSCRIPTION BY CBP

CBP 激活和抑制转录

• 批准号: 6216084
• 负责人: John Chrivia
• 金额: $ 6.81万
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6216084
• 关键词: antisense nucleic acid; cAMP response element binding protein; chimeric proteins; gene induction /repression; gene mutation; genetic promoter element; genetic transcription; immunoprecipitation; phosphorylation; point mutation; protein structure function; transcription factor; transfection

DESCRIPTION (adapted from the applicant's abstract: The objective of this application is to dissect the structure-function relationships of CREB binding protein, CBP. It is proposed to 1) characterize the domains of CBP which activate transcription; 2) characterize the structural domains within the activation domains of CBP; 3) identify the core transcriptional molecules which interact with CBP; and, 4) determine the domains within CBP which are required for E1A repression of CBP-mediated transcription.

描述（改编自申请人的摘要：此目的 应用是为了剖析CREB的结构功能关系 结合蛋白CBP。 提出了1）表征CBP的域 激活转录； 2）表征内部的结构域 CBP的激活域； 3）确定核心转录 与CBP相互作用的分子；以及，4）确定CBP内的域 E1A抑制CBP介导的转录所需的。