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C/EBP ALPHA AS MEDIATOR OF INSULIN ACTION IN ADIPOCYTES

C/EBP ALPHA AS MEDIATOR OF INSULIN ACTION IN ADIPOCYTES
C/EBP ALPHA 作为脂肪细胞中胰岛素作用的调节剂
批准号：
6341416
负责人：
Ormond A MacDougald
金额：
$6.01万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
项目状态：
已结题
起止时间：
1996-07-25 至 2001-03-31
来源：
https://reporter.nih.gov/project-details/6341416
关键词：
adipocytes affinity chromatography cell differentiation chimeric proteins confocal scanning microscopy dimer enhancer binding protein gel mobility shift assay gene expression genetic transcription hormone regulation /control mechanism insulin laboratory rat mutant northern blottings phosphorylation protein degradation protein kinase protein purification protein sequence protein structure function reporter genes site directed mutagenesis tissue /cell culture

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英文摘要
DESCRIPTION (Adapted from the applicant's abstract): The long-term goal of this project is to further the understanding of the role of the transcription factor C/EBPalpha in regulating adipocyte gene expression and metabolism. C/EBPalpha is induced during the differentiation of 3T3-L preadipocytes into adipocytes and activates the expression of genes involved in creating and maintaining the adipocyte phenotype, notably the insulin responsive glucose transporter Glut-4, adipocyte lipid binding protein 422/AP2, and stearoyl CoA desaturase 1 (SCD1) genes. The PI will test the effects of insulin-induced changes in phosphorylation on the activity of C/EBPalpha and elucidate the role of C/EBPalpha in regulating the expression of downstream adipocyte genes.
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