Multidisciplinary Training Program in Basic Diabetes Research

描述（由申请人提供）：糖尿病及其并发症的负担强调学术研究机构和糖尿病研究人员需要培训合格的研究科学家，以开发治疗、预防和治愈糖尿病的新途径。该培训补助金的主要目标是通过多学科和全面的学习经验、科学互动和指导，培训从事糖尿病研究职业的博士基础科学家，以深入了解糖尿病的分子方面。该培训项目植根于密歇根大学丰富的研究环境中，其中包括高度大学化、跨学科的糖尿病研究社区和生物医学研究的优秀核心资源。该培训计划建立在导师组在糖尿病发病机制及其并发症的不同组成部分的独特专业知识的基础上。培训资助导师分为六个主要兴趣组——胰岛生物学、自身免疫性糖尿病、脂肪细胞生物学、下丘脑代谢调节、胰岛素抵抗和代谢控制机制（肝脏、脂肪细胞和肌肉群）以及糖尿病并发症。该计划包括在单个实验室进行的培训，但以糖尿病分子发病机制的核心课程以及一系列跨学科和协作的教育项目会议、研讨会、活动为补充。 资助写作、职业发展和研究方法。该培训将为过渡到独立提供必要的工具。该项目包括 18 名导师，他们处于高度协作的环境中，拥有稳定的校外资金，他们在医学院的 9 个不同部门和内科系的两个部门任职。该计划将为密歇根糖尿病研究中心和营养与肥胖研究中心的培训任务提供重要补充。该培训计划将通过代谢内分泌学和糖尿病科进行管理，并由执行委员会监督，该执行委员会由首席研究员、一名联合主任和四名成员组成，其中四名成员是具有良好指导记录的高级研究人员。

DESCRIPTION (provided by applicant): The burden of diabetes and its complications stresses the need for academic research institutions and diabetes researchers to train well-qualified research scientists to develop new avenues for the treatment, prevention and cure of diabetes. The primary goal of this training grant is to train PhD basic scientists for careers in diabetes research using a multidisciplinary and comprehensive learning experience, scientific interactions and mentorship to develop a deep understanding of the molecular aspects of diabetes. This training program is embedded within the rich research environment of the University of Michigan, which includes a highly collegial, and interdisciplinary diabetes research community and excellent core resources for biomedical research. The training program builds on the unique expertise of the group of preceptors in different components of the pathogenesis diabetes and its complications. Training grant preceptors fall into six major interest groups - islt biology, autoimmune diabetes, adipocyte biology, hypothalamic regulation of metabolism, mechanisms of Insulin resistance and metabolic control (liver, adipocyte and muscle groups) and diabetes complications. The program includes training in the individual laboratory but is supplemented by a core curriculum in molecular pathogenesis of diabetes as well as an interdisciplinary and collaborative series of educational project meetings, seminars, activities in grant writing, career advance and research methodologies. This training will provide the necessary tools for transition to independence. This program includes 18 mentors in a highly collaborative environment with stable extramural funding who have appointments in nine separate departments in the School of Medicine and two Divisions within the Department of Internal Medicine. This program will provide a significant complement for the training mission of the Michigan Diabetes Research Center and the Nutrition and Obesity Research Center. The training program will be administered through the Division of Metabolism Endocrinology and Diabetes, and will be overseen by an executive committee comprising the Principal Investigator, one co-director and four members of whom are senior investigators with strong mentoring track records.