Multidisciplinary Training Program in Basic Diabetes Research

描述(申请人提供)：糖尿病及其并发症的负担突出表明，学术研究机构和糖尿病研究人员需要培养合格的研究科学家，以开发治疗、预防和治疗糖尿病的新途径。这一培训基金的主要目标是利用多学科和全面的学习经验、科学互动和指导，为糖尿病研究领域的职业培训博士基础科学家，以加深对糖尿病分子方面的理解。这一培训计划嵌入了密歇根大学丰富的研究环境中，其中包括高度合作的、跨学科的糖尿病研究社区和出色的生物医学研究核心资源。该培训计划建立在病机、糖尿病及其并发症的不同组成部分的专家小组的独特专业知识的基础上。培训赠款接受者分为六个主要兴趣组--胰岛素抵抗生物学、自身免疫性糖尿病、脂肪细胞生物学、下丘脑新陈代谢调节、胰岛素抵抗和代谢控制机制(肝脏、脂肪细胞和肌肉组)和糖尿病并发症。该计划包括个别实验室的培训，但补充了糖尿病分子发病机制的核心课程，以及一系列跨学科和协作的教育项目会议、研讨会、活动 格兰特写作、职业发展和研究方法。这项培训将为向独立过渡提供必要的工具。这一计划包括18名导师，他们在高度协作的环境中，拥有稳定的外部资金，他们在医学院的九个不同部门和内科的两个部门任职。该计划将为密歇根糖尿病研究中心和营养与肥胖研究中心的培训任务提供重要补充。培训方案将通过新陈代谢内分泌学和糖尿病司管理，并将由一个执行委员会监督，执行委员会由首席调查员、一名联席主任和四名成员组成，他们是具有良好指导记录的高级调查人员。

DESCRIPTION (provided by applicant): The burden of diabetes and its complications stresses the need for academic research institutions and diabetes researchers to train well-qualified research scientists to develop new avenues for the treatment, prevention and cure of diabetes. The primary goal of this training grant is to train PhD basic scientists for careers in diabetes research using a multidisciplinary and comprehensive learning experience, scientific interactions and mentorship to develop a deep understanding of the molecular aspects of diabetes. This training program is embedded within the rich research environment of the University of Michigan, which includes a highly collegial, and interdisciplinary diabetes research community and excellent core resources for biomedical research. The training program builds on the unique expertise of the group of preceptors in different components of the pathogenesis diabetes and its complications. Training grant preceptors fall into six major interest groups - islt biology, autoimmune diabetes, adipocyte biology, hypothalamic regulation of metabolism, mechanisms of Insulin resistance and metabolic control (liver, adipocyte and muscle groups) and diabetes complications. The program includes training in the individual laboratory but is supplemented by a core curriculum in molecular pathogenesis of diabetes as well as an interdisciplinary and collaborative series of educational project meetings, seminars, activities in grant writing, career advance and research methodologies. This training will provide the necessary tools for transition to independence. This program includes 18 mentors in a highly collaborative environment with stable extramural funding who have appointments in nine separate departments in the School of Medicine and two Divisions within the Department of Internal Medicine. This program will provide a significant complement for the training mission of the Michigan Diabetes Research Center and the Nutrition and Obesity Research Center. The training program will be administered through the Division of Metabolism Endocrinology and Diabetes, and will be overseen by an executive committee comprising the Principal Investigator, one co-director and four members of whom are senior investigators with strong mentoring track records.