ALCOHOL IN RISK BEHAVIORS AND NEUROBEHAVIORAL STATUS

描述(改编自摘要)：初步结果如下 研究小组提出，与预期相反，神经认知 感染HIV-1的非洲裔美国男性的缺陷与 饮酒，但不是为了使用可卡因。在此应用程序中， 首席调查员建议对这些最初的 对非常富有的人进行了一系列有重点的二次分析的发现 NIDA资助的非裔美国人健康项目中收集的数据集 (AAHP)。这项研究旨在检查神经行为的影响 艾滋病毒/艾滋病和艾滋病毒阳性和艾滋病患者社区样本中的物质使用情况 艾滋病病毒阴性的非洲裔美国男性，可以说是最大的社区样本 对高危非裔美国人进行了评估 全面的神经生物学、精神病学和心理社会措施。 在这项申请中，提出了两项平行研究。在研究1中， 研究人员将研究酒精对高危性行为的影响 行为，无论是独立的，还是被非法药物使用和 190例HIV阳性者和312例HIV阳性者的其他心理社会影响因素 艾滋病毒阴性的男人。在第二项研究中，他们将考察 酒精对老年人神经认知功能和神经认知干酪性的影响 502名男性的完整样本。研究人员还将研究 酒精在神经生理状态和功能中的作用 118例HIV阳性患者分层样本的局部血流量 和HIV阴性的男性使用最先进的神经成像技术 (MRI、MRS、SPECT)。在这些分析中，研究人员将采取 因此，使用相对成本的唯一数据集的优势 提高我们对酒精作用的认识的有效方法 在这个研究不足的人群中，艾滋病的风险很大。

DESCRIPTION (adapted from the Abstract): Preliminary results from this research team suggest that contrary to expectations, neurocognitive deficits among African American men infected with HIV-1 are related to alcohol consumption, but not to the use of cocaine. In this application, the Principal Investigator proposes to follow-up on those initial findings with a series of focused secondary analyses on the very rich dataset collected in the NIDA-funded African American Health Project (AAHP). The study is designed to examine the neurobehavioral effects of HIV/AIDS and substance use in a community sample of HIV-positive and HIV-negative African American men, arguably the largest community sample of high-risk African American who have been assessed with a comprehensive neurobiological, psychiatric, and psychosocial measures. Two parallel studies are proposed in this application. In Study #1, the researchers will examine the contribution of alcohol to high risk sexual behaviors, both independently and as modified by illicit drug use and other psychosocial co-factors in a sample of 190 HIV-positive and 312 HIV-negative men. In Study #2, they will examine the contribution of alcohol to neurocognitive functioning and neurcognitive caseness in the full sample of 502 men. The researchers will examine, also, the role of alcohol in neurophysiologic status and functioning as indexed by regional blood flow (rCBF) in a stratified sample of 118 HIV-positive and HIV-negative men using state-of-the-art neuroimaging techniques (MRI, MRS, SPECT). In these analyses, the researchers will take advantage of a unique dataset using, thereby, a relatively cost- effective means to enhance our understanding of the role alcohol plays in HIV disease in this understudied population.