BIOBEHAVIORAL EFFECTS OF MINDFULNESS-BASED STRESS REDUCTION IN HIV

基于正念的减压疗法对艾滋病毒患者的生物行为影响

• 批准号: 7718006
• 负责人: HECTOR FRANKLIN MYERS
• 金额: $ 11.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718006
• 关键词: Clinical effectiveness; Computer Retrieval of Information on Scientific Projects Database; Condition; Disease Progression; Funding; Grant; HIV; Immune; Institution; Mediating; Meditation; Personal Satisfaction; Quality of life; Research; Research Personnel; Resources; Source; Stress and Coping; T-Lymphocyte; T-Lymphocyte Subsets; Training; United States National Institutes of Health; Viral Load result; Writing; base; biobehavior; immune resistance; improved; indexing; mindfulness-based stress reduction; programs; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to determine whether the Mindfulness-Based Reduction (MBSR) program is more effective than a stress and coping writing control condition (SCW) in: (1) improving immune resistance and delaying HIV disease progression (i.e. increases in T-lymphocyte subsets and reductions in viral load), (2) improving psychological status and quality of life, and (3) to determine whether these effects are moderated by the amount of practice and mediated by changes in mindfulness. We hypothesize, consistent with the evidence to date, that: (1) MBSR training will elicit greater improvements in immune status as indexed by increases in T-lymphocytes than the control condition, (2) although there is no evidence of the clinical effectiveness of MBSR with HIV to date, we hypothesize that mindfulness training will produce greater reductions in viral load compared to the control condition, and (3) that mindfulness training will produce greater improvements in psychological status and well-being than the control condition. Finally, we also hypothesize (4) that the magnitude of immune and psychological changes will be moderated by the amount of practice and mediated by increases in mindfulness.

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