FASEB SUMMER CONFERENCE-- FOLATE, B12 AND 1C METABOLISM

描述(申请人的描述) 请拨资金为第八届FASEB夏季研究提供部分支持 叶酸、维生素B12和一碳代谢会议将举行 由美国实验学会联合会赞助 生物学(FASE B)将于2000年8月5日至8月10日在科罗拉多州斯诺马斯村举行。 这次会议为临床科学家提供了一个独特的机会，基础 科学家，以及来自广泛群体的参与科学政策的人 学科之间进行正式和非正式的互动。相遇相遇 去年，最近六次会议已全部认购，并参加在 本次会议将限制为210人参加。请拨出资金以 允许研究生、住院医生和博士后研究员，并建立 国内和国际科学家出席会议。一个详细的 提出的计划包括著名的科学家以及 初级科学家刚刚进入这一领域。此外，主题还涵盖 从当前的临床问题到最大的 尖端的生化和生物物理研究。会议一直在进行 (1)一碳代谢：酶学与调控；(2) 同型半胱氨酸代谢和病理生理学；(3)蛋氨酸代谢： 酶学及其调控(4)甲基代谢(5)转位 叶酸和B12代谢物；(6)以叶酸依赖的酶反应为靶点 用于化疗；(7)治疗中的叶酸和抗叶酸；(8)B12 合成和依赖B12的酶；(9)叶酸、维生素的遗传性疾病 B12和同型半胱氨酸代谢。除了正式的演讲外， 该计划将与海报会议和研讨会相辅相成。第一 研讨会将更新各种降低同型半胱氨酸维生素的进展 心血管疾病预防干预试验。第二个遗嘱 讨论食品叶酸强化作为一项公共政策。这些产品提供了许多 非正式讨论的机会，并允许研究生、住院医生 和博士后研究员，以及知名科学家，有机会 介绍并讨论他们的工作。提出的最有趣的新研究 将以以下形式向更广泛的受众传播 在FASEB期刊上发表了一篇或多篇“最先进的”评论。

DESCRIPTION (Applicant's Description) Funds are requested for partial support of the 8th FASEB Summer Research Conference on Folic Acid, Vitamin B12 and One Carbon Metabolism, to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB) from August 5 - August 10, 2000 at Snowmass Village, Colorado. This conference offers a unique opportunity for clinician scientists, basic scientists, and those involved in science policy from a broad group of disciplines to interact both formally and informally. Meeting every other year, the last six conferences have been fully subscribed and participation at this conference will be limited to 210 individuals. Funds are requested to allow graduate students, residents and postdoctoral fellows, and established national and international scientists to attend the meeting. A detailed program is presented which includes well established scientists as well as junior scientists just entering the field. In addition, topics cover the entire spectrum from current clinical problems to areas of the most sophisticated biochemical and biophysical research. Sessions have been scheduled on (1) One carbon metabolism: Enzymology and regulation; (2) Homocysteine metabolism and pathophysiology; (3) Methionine Metabolism: Enzymology and regulation (4) Methyl group metabolism (5) Translocation of folate and B12 metabolites; (6) Folate-dependent enzyme reactions as targets for chemotherapy; (7) Folates and antifolates in therapeutics; (8) B12 Synthesis and B12-dependent Enzymes; (9) Genetic diseases of folate, vitamin B12 and homocysteine metabolism. In addition to the formal presentations, the program will be complemented with poster sessions and workshops. The first workshop will update progress of the various homocysteine-lowering vitamin intervention trials for cardiovascular disease prevention. The second will discuss food folate fortification as a public policy. These offer many opportunities for informal discussions and allow graduate students, residents and postdoctoral fellows, as well as established scientists, an opportunity to present and discuss their work. The most interesting new research presented at the conference will be disseminated to a much wider audience in the form of one or more "state-of-the-art" reviews in the FASEB Journal.