GORDON CONFERENCE:HORMONAL & NEURAL PEPTIDE BIOSYNTHESIS

戈登会议：荷尔蒙

• 批准号: 6159568
• 负责人: ROBERTA S. FULLER
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6159568
• 关键词: hormone biosynthesis; meeting /conference /symposium; travel

DESCRIPTION (taken from the application) Bioactive peptides serve diverse functions as signaling molecules, both in neural and endocrine physiology and during morphogenesis and development. The generation of small peptides from larger precursor proteins during their transit of the secretory pathway, or sometimes from cytosolic precursors, involves multiple post-translational modifications that include endo- and exo-proteolysis, oxidative cleavage (C-terminal "amidation"), acetylation, and lactone formation, among others. In the past two decades, active areas of research have moved from the identification of peptide precursors, polyproteins, etc., to the identification of the enzymes involved in processing reactions and studies of the specificity, mechanism and structures of the enzymes. The action of processing enzymes on substrate precursors within the lumenal domain of the secretory pathway has made it clear that understanding mechanisms and regulation of sorting, transport and localization of both soluble and membrane proteins is crucial to understanding the biosynthesis of signaling peptides. Access to the genes encoding processing enzymes has made it possible to initiate genetic approaches to begin to elucidate the precise physiological roles of these enzymes in mammals. These studies are complemented by simple eukaryotic systems: unicellular eukaryotes such as yeast and protozoans and invertebrate metazoans such as Drosophila and C. elegans. Analogous processing reactions continue to be of comparative interest to the field. This is an application for partial support for the fourth Gordon Research Conference on Hormonal and Neural Peptide Biosynthesis, to be held July 16-21, 2000, at Colby-Sawyer College in New London, NH. In the tradition of the previous three meetings, this meeting will be multi-disciplinary, bringing together scientists from diverse fields, ranging from enzymology and structural biology to cell biology and neurobiology to genetics and physiology. At the same time, the session topics and speakers will be chosen to focus precisely on the vital and current issues in the synthesis and secretion of peptide hormones, neuropeptides and related molecules. NIH funding is requested to support the travel, registration and lodging of 10 junior faculty, fellows and students who will give platform presentations during the meeting. At least 6 recipients of this support will be chosen from applicants to the meeting who have submitted abstracts and requested that they be considered for a platform talk. Recipients of the awards will be chosen by the Vice Chair in conjunction with members of the organizing committee. Without a separate source of funding, we would be unable to provide financial support for this Awards program.

描述（取自应用程序） 生物活性肽作为信号分子具有不同的功能， 神经和内分泌生理学以及形态发生和发育期间。的 小肽的产生是由较大的前体蛋白质在其 分泌途径的转运，或有时从胞质前体， 涉及多个翻译后修饰，包括内切和 外切蛋白水解、氧化裂解（C-末端“酰胺化”）、乙酰化和 内酯形成等。在过去的二十年里， 研究已经从肽前体的鉴定， 多蛋白等，对参与加工的酶的鉴定 反应和研究的特异性，机制和结构， 内切酶加工酶对底物前体的作用， 分泌途径的内腔结构域已经清楚地表明， 分类、运输和定位的机制和调节 可溶性蛋白和膜蛋白对于理解 信号肽对编码加工酶的基因的研究 有可能启动遗传方法，开始阐明精确的 这些酶在哺乳动物中的生理作用。这些研究补充了 通过简单的真核系统：单细胞真核生物，如酵母和 原生动物和无脊椎后生动物如果蝇和C.优美的 类似的加工反应继续对本领域的技术人员具有比较大的兴趣。 领域 这是对第四个戈登研究的部分支持的申请 激素和神经肽生物合成会议，将于7月16日至21日举行， 2000年，在新罕布什尔州新伦敦的科尔比索耶学院。在传统的 前三次会议，这次会议将是多学科， 聚集了来自不同领域的科学家，从酶学和结构 从生物学到细胞生物学，从神经生物学到遗传学和生理学。在 同时，会议主题和发言人的选择将集中在 肽合成和分泌中的重要和当前的问题 激素、神经肽和相关分子。国家卫生研究院的资金要求， 支持旅行，注册和住宿的10个初级教师，研究员和 学生们将在会议期间发表演讲。至少6 这项支持的接受者将从会议的申请者中选出， 我提交了摘要，并要求考虑将其作为平台 谈谈获奖者将由副主席与 和组委会的成员一起。如果没有单独的资金来源， 我们将无法为该奖项计划提供资金支持。