ROLE OF NEURAL PLASTICITY IN CHEMICAL INTOLERANCE

神经可塑性在化学不耐受中的作用

• 批准号: 6095303
• 负责人: Barbara A Sorg
• 金额: $ 1.2万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6095303
• 关键词: chemical hypersensitivity; meeting /conference /symposium; neural plasticity

The New York Academy of Sciences is sponsoring a conference entitled: Role of Neural Plasticity in Chemical Intolerance in June 2000. The principal investigator and chair is Barbara Sorg, Ph.D., Washington State University. The co-chair is Iris Bell, M.D., Ph.D., Tucson Veterans Affairs Medical Center. Chemical intolerance (CI), also referred to as multiple chemical sensitivity, is a condition whereby individuals become increasingly sensitive to chemicals in the home and workplace. It is an emerging problem in environmental health. A wide variety of symptoms and severe illness from low-level chemical exposures have been reported in as high as 4-6% of the American population. Individuals with sensitivities to chemicals make an average of 23 health care provider visits per year. Thus, the economic impact of the CI condition and lack of treatment is potentially enormous. The main objective of the meeting is to gather neuroscientists from a variety of subdisciplines to discuss the potential mechanisms for the amplification of symptoms in individuals with CI. The meeting will provide a forum for the exchange of ideas in these subdisciplines in an effort to develop a series of testable hypotheses based upon the postulate that neural plasticity plays a role in the development of CI. While the primary focus of the meeting is on pre-clinical data, the program will also include scientists who will provide up-to-date information on the clinical aspects of CI. It is expected that these presentations by clinical and basic scientists will familiarize the audience with not only the primary clinical findings of CI but also basic biological findings related to neural plasticity as a potential critical link for mechanisms leading to CI in humans. The basic science findings will focus primarily on the cellular changes that mediate plasticity as well as alterations in brain pathways that regulate behavior. The findings will be integrated into a rationale for future basic research and clinical applications. Ultimately, the goal is to provide a greater understanding of the mechanism(s) of CI so that treatment strategies may be developed. The proceedings will be published as a volume in the Annals of the New York Academy of Sciences and will be distributed internationally.

纽约科学院将于2000年6月主办一次会议，题为：神经可塑性在化学耐受中的作用。首席研究员和主席是华盛顿州立大学的Barbara sog博士。联合主席是图森退伍军人事务医疗中心的Iris Bell医学博士。化学不耐受（CI），也被称为多重化学敏感性，是一种个人对家庭和工作场所的化学物质越来越敏感的情况。这是环境卫生领域的一个新问题。据报道，高达4% -6%的美国人因接触低剂量化学物质而出现各种各样的症状和严重疾病。对化学品敏感的人平均每年要到卫生保健机构就诊23次。因此，CI状况和缺乏治疗的经济影响可能是巨大的。会议的主要目的是聚集来自不同分支学科的神经科学家，讨论CI患者症状放大的潜在机制。会议将为这些分支学科的思想交流提供一个论坛，以努力发展一系列可测试的假设，这些假设基于神经可塑性在CI的发展中起作用的假设。虽然会议的主要焦点是临床前数据，但该计划也将包括科学家，他们将提供有关CI临床方面的最新信息。预计这些临床和基础科学家的演讲将使听众不仅熟悉脑损伤的主要临床发现，而且熟悉与神经可塑性相关的基本生物学发现，神经可塑性是导致人类脑损伤机制的潜在关键环节。基础科学发现将主要集中在调节可塑性的细胞变化以及调节行为的大脑通路的改变上。这些发现将被整合到未来基础研究和临床应用的理论基础中。最终，我们的目标是对CI的机制有更深入的了解，以便制定治疗策略。会议记录将作为一卷出版在《纽约科学院年鉴》上，并将在国际上分发。