HOST / GUEST INTERACTIONS IN CATANIONIC VESICLES

描述（来自摘要）：两亲性分子，如表面活性剂和 磷脂自组装产生复杂的分级结构 包括由球形疏水双层组成的单层囊泡 将内部水室与外部介质分隔开的壳。 该双层由表面活性剂分子的双层（“内层”）组成。 和“外”小叶）具有不同程度的表面活性剂填充。这 形态学为包封，分离， 和/或“客体”试剂的浓度。尺寸的变化和 囊泡“宿主”系统的表面电荷可以促进 量身定制的客人位置和送货车辆。本项目拟 继续研究非共价相互作用， 蒽环类抗生素在细胞膜、脂质体和 其他膜模型系统。光散射测量和荧光 光谱研究将被用来表征之间的对应关系 囊泡尺寸和客体分布以及囊泡表面活性剂组成。

DESCRIPTION (from abstract): Amphiphilic molecules such as surfactants and phospholipids self assemble to generate complex hierarchical structures including unilamellar vesicles consisting of spherical hydrophobic bilayer shells that separate an inner aqueous compartment from the external medium. This bilayer consists of a double layer of surfactant molecules (the "inner" and "outer" leaflets) with different degrees of surfactant packing. This morphology provides distinct microenvironments for encapsulation, isolation, and/or concentration of "guest" reagents. Variations of the dimensions and surface charges of the vesicle "host" systems could facilitate the design of tailored guest location and delivery vehicles. The current project proposes to continue the examination of non-covalent interactions that dictate the distribution of anthracycline antibiotics within cell membranes, liposomes, and other membrane model systems. Light scattering measurements and fluorescence spectroscopic studies will be used to characterize the correspondence between vesicle dimensions and guest distribution and vesicle surfactant composition.