PROSTAGLANDIN EXCRETION IN PREECLAMPSIA

前列腺素代谢紊乱目前被认为是一种 先兆子痫发病机制的主要机制。 最 然而，以前对这一理论的研究只包括那些 已经出现了临床上明显的疾病。 为了研究 前列腺素异常是否先于先兆子痫发作，我们 我设计了一个巢式病例对照研究， 前瞻性收集早在妊娠13周的妇女 参与NICHD钙预防先兆子痫试验 （CPEP）。 在这项研究中，我们比较了 子痫前期妇女诊断前前列腺素和血栓素水平 子痫前期与正常妊娠妇女在相当的 胎龄 实验室分析已经完成， 分析正在进行中。

A disturbance of prostaglandin metabolism is currently believed to be one of the major mechanisms in the pathogenesis of preeclampsia. Most previous studies of this theory, however, have included only women who had already developed clinically overt disease. In order to investigate whether prostaglandin abnormalities precede the onset of preeclampsia, we have designed a nested case-control study using stored urine specimens prospectively collected as early as thirteen weeks gestation from women participating in the NICHD Trial of Calcium to Prevent Preeclampsia (CPEP). In this study, we are comparing the urinary excretion of prostaglandin and thromboxane in preeclampsic women before the diagnosis of preeclampsia to that in normal pregnant women at comparable gestational ages. The laboratory analyses have been completed and data analysis is ongoing.