Optimising the bone and cardiovascular response to dietary calcium: a physiological approach in experimental models

优化骨骼和心血管对膳食钙的反应：实验模型中的生理方法

• 批准号: nhmrc : 567101
• 负责人: Ms Tania Romano
• 金额: $ 2.38万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/optimising-bone-cardiovascular-experimental-models/116048
• 关键词: Optimising; bone; cardiovascular; response; dietary

We aim to identify a variable calcium diet that optimises bone mass, density and strength as well as blood pressure in a rat model of intrauterine growth restriction. We propose that a moderate calcium diet followed by a high calcium diet is beneficial for bone and heart health. This is based on the physiological effect of reduced calcium intake stimulating intestinal calcium absorption. This represents a novel research approach to improving calcium intake, bone as well as heart health.

我们的目标是确定一种可变的钙饮食，在宫内生长受限的大鼠模型中优化骨量、密度和强度以及血压。我们认为，适量的钙饮食和高钙饮食有利于骨骼和心脏的健康。这是基于减少钙摄入量刺激肠道钙吸收的生理效应。这代表了一种改善钙摄入量、骨骼和心脏健康的新研究方法。