NUTRITIONAL STATUS OF HIV INFECTED INJECTION DRUG USERS

感染艾滋病毒的注射吸毒者的营养状况

• 批准号: 6174798
• 负责人: ALICE M TANG
• 金额: $ 30.69万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-25 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6174798
• 关键词: AIDS therapy; HIV infections; antiAIDS agent; antioxidants; blood chemistry; body composition; clinical research; diet; human subject; intravenous drug abuse; longitudinal human study; nutrition; nutrition related tag; oxidative stress; protease inhibitor

This proposed study is a competing renewal of a study on the nutritional status of HIV-positive and HIV-negative injection drug users (IDU) (NIDA-DA10252). Results from the first year of this 2.5 year grant indicate that serum antioxidant vitamins were similar between HIV-positive and HIV-negative IDUs. However, those HIV-positive participants on antiretroviral combination therapies (ART) including a protease inhibitor (PI) had significantly higher mean serum levels of several antioxidant vitamins compared to both HIV-negatives and HIV-positives not taking PI's. This difference was not explained by differences in dietary intake or supplement use. These results suggest that oxidative stress, as measured by serum antioxidants, may be reduced in patients taking PI's; however, this requires further investigation. Specifically, we would like to examine the associations between oxidative stress and serum antioxidant levels among HIV-negative IDUs and HIV-positive IDUs on various ART regimens. We will also examine the effect of oxidative stress and serum antioxidant levels on HIV disease progression. Furthermore, we have the opportunity to characterize a group of more active IDUs, many of whom are not on ART, with respect to oxidative stress and antioxidant status. The proposed renewal will build on the existing study (TANG - The ALIVE Nutrition Group) and the infrastructure of the ongoing ALIVE study (NIDA-DA04334). In addition to the subjects already enrolled in TANG (n=398), we plan to enroll 52 additional HIV-positive ALIVE participants to increase the sample size of each ARV therapy group to 50; 100 HIV-positive subjects who report injecting drugs at least 3 times a week, who have recently been recruited into the ALIVE study; and 30 HIV negative never-drug using volunteers from the community. Study participants will undergo dietary intake interviews, body composition measurements, and venipuncture for serum measures of oxidative stress and antioxidants. Participants will be followed for HIV-related outcomes for up to four years. The results from this observational study may help to guide the design of more effective interventions of antioxidant supplementation in the era of PI's.

这项拟议的研究是一项关于HIV阳性和HIV阴性注射吸毒者（IDU）营养状况的研究（NIDA-DA 10252）的竞争性更新。 这项为期2.5年的补助金的第一年的结果表明，艾滋病毒阳性和艾滋病毒阴性注射吸毒者之间的血清抗氧化维生素相似。 然而，那些接受抗逆转录病毒联合治疗（ART）（包括蛋白酶抑制剂（PI））的HIV阳性参与者与HIV阴性和HIV阳性未服用PI的参与者相比，几种抗氧化维生素的平均血清水平显着较高。 这种差异不能用饮食摄入或补充剂使用的差异来解释。 这些结果表明，通过血清抗氧化剂测量的氧化应激可能会在服用PI的患者中减少;然而，这需要进一步研究。具体来说，我们想研究氧化应激和血清抗氧化剂水平之间的关联，艾滋病毒阴性的注射吸毒者和艾滋病毒阳性的注射吸毒者在各种ART方案。 我们还将研究氧化应激和血清抗氧化剂水平对HIV疾病进展的影响。 此外，我们有机会描述一组更活跃的注射吸毒者，其中许多人没有接受抗逆转录病毒治疗，关于氧化应激和抗氧化状态。拟议的更新将建立在现有研究（TANG - The ALIVE Nutrition Group）和正在进行的ALIVE研究（NIDA-DA 04334）的基础设施上。 除了已经入组TANG的受试者（n=398）外，我们计划再入组52名HIV阳性ALIVE受试者，以将每个ARV治疗组的样本量增加至50名; 100名最近被招募到ALIVE研究中的报告每周至少注射3次药物的HIV阳性受试者;以及30名来自社区的HIV阴性从不使用药物的志愿者。 研究参与者将接受饮食摄入访谈、身体成分测量和静脉穿刺，以测量氧化应激和抗氧化剂的血清。 参与者将接受长达四年的艾滋病毒相关结果的随访。 这项观察性研究的结果可能有助于指导PI时代更有效的抗氧化剂补充干预措施的设计。