NUTRITIONAL STATUS IN HIV 1 PATIENTS IN BALTIMORE, MD

描述：(申请人摘要) 这项研究的目的是描述一个人的营养状况 对注射吸毒者(IDU)进行队列调查，并检查其相互关系 营养状况、饮食摄入量和HIV-I感染之间的关系。这个 拟议的研究将在Alive研究中利用现有的注射吸毒者队列， 在马里兰州巴尔的摩，由NIH/NIDA赞助的持续队列。这一群人 由2,921名吸毒者组成，他们于1988年被招募并被跟踪 每半年一次，以了解艾滋病毒-1感染的自然历史。之前的研究， 主要是同性恋/双性恋男性，表明营养状况是 在HIV-1感染中很重要，并可能影响疾病的进展。一点儿 关于饮食习惯和/或营养状况的研究已经发表 吸毒者。IDU可能代表着一个相当不同的群体， 在营养状况方面，他们也有感染艾滋病毒-1的风险。 因此，他们形成了一个理想的群体，可以在其中检查 这些因素之间的关系。200名艾滋病毒阳性者(125名男性，75名 女性)和200名艾滋病毒阴性(125名男性，75名女性)参与者 Alive研究将被纳入拟议的营养研究。这些 每半年对受试者进行一次为期18个月的跟踪调查。在三个中的每一个 访问，营养评估将包括人体测量 (身高、体重、四个部位的皮褶厚度和肘部 广度)，生物电阻抗分析，24小时饮食召回 调查问卷，六个月的食物频率调查问卷，以及一些 关于饮食习惯和体力活动的其他问题。鲜血将会是 用于评估第一次营养时的血清/血浆营养水平 参观。 这项研究的具体目的是：1)表征 一大群以社区为基础的男性的状况和食物摄入模式 和女性注射吸毒者，感染和不感染HIV-1；2)验证营养 从六个月的食物频率问卷中获得的摄入量 从重复的24小时召回中获得；3)检查关联 中国人群营养状况、免疫功能与HIV-1感染状况的关系 IDU的；以及4)检查频率、持续时间和 现任和前任注射吸毒者的药物使用类型和营养状况 营养状况和艾滋病毒疾病进展之间的联系也将 将在本提案的18个月后续期间进行评估。使用 这些数据，我们将能够评估异质性的数量 并决定了研究的可行性 营养状况和/或评估注射吸毒者的饮食摄入量。 这里收集的信息可以作为基线营养数据用于 未来的流行病学和干预性研究的关系 活人的营养状况、HIV-1感染和艾滋病进展 一群人。

DESCRIPTION: (Applicant's Abstract) The purpose of this study is to characterize the nutritional status of a cohort of injecting drug users (IDU's) and to examine the relationships between nutritional status, dietary intake, and HIV-I infection. The proposed study will utilize an existing cohort of IDU's in the ALIVE study, an ongoing NIH/NIDA-sponsored cohort in Baltimore, Maryland. This cohort consists of 2,921 IDU's who were recruited in 1988 and have been followed semiannually for the natural history of HIV- 1 infection. Previous studies, mainly in gay/bisexual men, have suggested that nutritional status is important in HIV-1 infection and may influence disease progression. Little research has been published on the dietary habits and/or nutritional status of drug addicts. IDU's may represent a fairly heterogeneous group with regard to nutritional status and they are also at risk for HIV- 1 infection. Therefore, they form an ideal population in which to examine the relationships between these factors. Two hundred HIV-positive (125 male, 75 females) and 200 HIV-negative (125 male, 75 female) participants of the ALIVE study will be recruited into the proposed nutrition study. These subjects will be followed, semi-annually, for 18 months. At each of three visits, nutritional assessment will consist of anthropometric measurements (height, weight, four-site skinfold thickness measurements, and elbow breadth), bioelectrical impedance analysis, a 24-hour dietary recall questionnaire, a six-month food frequency questionnaire, and a few additional questions on dietary habits and physical activity. Blood will be drawn for estimation of serum/plasma nutrient levels at the first nutrition visit. The specific aims of this study are: 1) to characterize the nutritional status and food intake patterns of a large cohort of community-based, male and female IDU's, with and without HIV-1 infection; 2) to validate nutrient intakes obtained from the six-month food frequency questionnaires with those obtained from the replicate 24-hour recalls; 3) to examine the association between nutritional status, immune function, and HIV- 1 disease status in IDU's; and 4) to examine the association between frequency, duration and type of drug use and nutritional status in current and former IDU's. The association between nutritional status and HIV disease progression will also be assessed during the 18-month follow-up period of this proposal. With these data, we will be able to assess the amount of heterogeneity that exists in this population and determine the feasibility of studying nutritional status and/or assessing dietary intake in IDU's. The information collected here could be used as baseline nutrition data for future epidemiologic and intervention studies on the relationships between nutritional status, HIV-1 infection, and AIDS progression in the ALIVE cohort.