NUTRITIONAL STATUS IN HIV 1 PATIENTS IN BALTIMORE, MD

描述：（申请人摘要） 这项研究的目的是描述一个营养状况， 注射毒品使用者（IDU's）的队列，并审查 营养状况、饮食摄入和HIV感染之间的关系。 的 拟议的研究将利用ALIVE研究中现有的IDU队列， 一项正在进行的NIH/NIDA赞助的队列研究，在马里兰州的巴尔的摩进行。 该队列 包括2，921名于1988年招募的注射吸毒者， 每半年一次，以了解HIV- 1感染的自然史。 以前的研究， 主要发生在男同性恋/双性恋男性中，这表明营养状况 在HIV-1感染中起重要作用，并可能影响疾病进展。 小 已经发表了关于饮食习惯和/或营养状况的研究， 吸毒成瘾者。 IDU可能代表一个相当异质的群体， 他们的营养状况也很差，而且他们也有感染艾滋病毒的危险。 因此，他们形成了一个理想的人口，在其中检查 这些因素之间的关系。 200名艾滋病毒阳性者（125名男性，75名 女性）和200名艾滋病毒阴性（125名男性，75名女性）的参与者。 ALIVE研究将被招募到拟定的营养研究中。 这些 每半年对受试者进行一次随访，持续18个月。 由分别来自三 营养评估将包括人体测量 （身高、体重、四个部位皮褶厚度测量和肘部测量） 宽度），生物电阻抗分析，24小时饮食回忆 调查问卷，六个月的食物频率调查问卷，以及一些 关于饮食习惯和体育活动的其他问题。 罪要归 用于估计首次营养时的血清/血浆营养水平 访问 本研究的具体目的是：1）表征营养 一个大型社区男性队列的状况和食物摄入模式 和女性注射吸毒者，有和没有HIV-1感染; 2）验证营养素 从六个月的食物频率问卷中获得的摄入量， 从重复的24小时召回中获得; 3）检查 营养状况、免疫功能和HIV- 1疾病状况之间的关系， IDU的;和4）检查频率，持续时间和 目前和以前注射吸毒者的药物使用类型和营养状况。 的 营养状况和艾滋病进展之间的联系也将 在本建议的18个月后续期内进行评估。 与 这些数据，我们将能够评估异质性的数量， 存在于这个群体中，并确定研究的可行性 营养状况和/或评估IDU的饮食摄入量。 的 这里收集的信息可以作为基线营养数据， 未来的流行病学和干预研究之间的关系， ALIVE中的营养状况、HIV-1感染和艾滋病进展 队列。

DESCRIPTION: (Applicant's Abstract) The purpose of this study is to characterize the nutritional status of a cohort of injecting drug users (IDU's) and to examine the relationships between nutritional status, dietary intake, and HIV-I infection. The proposed study will utilize an existing cohort of IDU's in the ALIVE study, an ongoing NIH/NIDA-sponsored cohort in Baltimore, Maryland. This cohort consists of 2,921 IDU's who were recruited in 1988 and have been followed semiannually for the natural history of HIV- 1 infection. Previous studies, mainly in gay/bisexual men, have suggested that nutritional status is important in HIV-1 infection and may influence disease progression. Little research has been published on the dietary habits and/or nutritional status of drug addicts. IDU's may represent a fairly heterogeneous group with regard to nutritional status and they are also at risk for HIV- 1 infection. Therefore, they form an ideal population in which to examine the relationships between these factors. Two hundred HIV-positive (125 male, 75 females) and 200 HIV-negative (125 male, 75 female) participants of the ALIVE study will be recruited into the proposed nutrition study. These subjects will be followed, semi-annually, for 18 months. At each of three visits, nutritional assessment will consist of anthropometric measurements (height, weight, four-site skinfold thickness measurements, and elbow breadth), bioelectrical impedance analysis, a 24-hour dietary recall questionnaire, a six-month food frequency questionnaire, and a few additional questions on dietary habits and physical activity. Blood will be drawn for estimation of serum/plasma nutrient levels at the first nutrition visit. The specific aims of this study are: 1) to characterize the nutritional status and food intake patterns of a large cohort of community-based, male and female IDU's, with and without HIV-1 infection; 2) to validate nutrient intakes obtained from the six-month food frequency questionnaires with those obtained from the replicate 24-hour recalls; 3) to examine the association between nutritional status, immune function, and HIV- 1 disease status in IDU's; and 4) to examine the association between frequency, duration and type of drug use and nutritional status in current and former IDU's. The association between nutritional status and HIV disease progression will also be assessed during the 18-month follow-up period of this proposal. With these data, we will be able to assess the amount of heterogeneity that exists in this population and determine the feasibility of studying nutritional status and/or assessing dietary intake in IDU's. The information collected here could be used as baseline nutrition data for future epidemiologic and intervention studies on the relationships between nutritional status, HIV-1 infection, and AIDS progression in the ALIVE cohort.