COCAINE, CAFFEINE AND NICOTINE--ORAL ABUSE AND BEHAVIOR

可卡因、咖啡因和尼古丁——口腔滥用和行为

• 批准号: 6124921
• 负责人: CHYAN E LAU
• 金额: $ 22.42万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6124921
• 关键词: barbiturates; behavioral /social science research tag; brain metabolism; caffeine; cocaine; conditioning; drug abuse therapy; drug addiction; drug administration rate /duration; drug adverse effect; injection /infusion; laboratory rat; midazolam; nicotine; oral administration; oral behavior; pharmacokinetics; phencyclidine; preference; reinforcer; relapse /recurrence; self medication; substance abuse related behavior; thirst; water drinking behavior

DESCRIPTION: (Applicant's Abstract) Experiments with rats will determine whether drug doses (cocaine, PCP, caffeine, midazolam, hexobarbital, nicotine) that are delivered by either intragastric or IV cannula contingent upon drinking a specific fluid can institute an oral preference for the solution drunk, whether it is (a) a drug solution or (b) a neutral-flavored solution, in order to ascertain whether oral drug preferences and abuse can be initiated solely by pharmacological events, a relation not yet clearly established. The pharmacological events (e.g., serum drug and metabolite levels) consequent to gastric and IV drug delivery will be delineated, as well as the intragastric and IV drug reinforcement thresholds, to effect the pharmacokinetic-pharmacodynamic modeling of drug reinforcement, which clarification may prove useful in the design of drug agonist therapies. The pharmacological events initiating and sustaining oral drug self-administration will be compared to the environmental events (schedule-induced polydipsia) which also can give rise to chronic oral drug self-administration. The degree to which drug self-administration compromises ensuing timing behavior will measure the behaviorally toxic consequences of acute and chronic drug-taking. Temporal, stimulus control, and pharmacological factors affecting the relapse to oral cocaine solution preference will be evaluated.

描述：（申请人摘要）

项目成果

Midazolam withdrawal and discriminative motor control: effects of FG 7142 and Ro 15-1788.

咪达唑仑戒断和辨别运动控制：FG 7142 和 Ro 15-1788 的影响。

• DOI: 10.1016/0091-3057(91)90191-4
• 发表时间: 1991
• 期刊: Pharmacology, biochemistry, and behavior
• 作者: Vigorito,M;Lau,CE;Tang,M;Falk,JL
• 通讯作者: Falk,JL

Sustained synergism by chronic caffeine of the motor control deficit produced by midazolam.

长期咖啡因对咪达唑仑产生的运动控制缺陷有持续的协同作用。

• DOI: 10.1016/0091-3057(91)90076-e
• 发表时间: 1991
• 期刊: Pharmacology, biochemistry, and behavior
• 作者: Lau,CE;Falk,JL
• 通讯作者: Falk,JL

Simultaneous determination of cocaine and its metabolites with caffeine in rat serum microsamples by high-performance liquid chromatography.

高效液相色谱法同时测定大鼠血清微量样品中的可卡因及其代谢物和咖啡因。

• DOI: 10.1016/s0378-4347(00)83755-x
• 发表时间: 1990
• 期刊: Journal of chromatography
• 作者: Lau,CE;Ma,F;Falk,JL
• 通讯作者: Falk,JL

Addictive behavior with and without pharmacologic action: critical role of stimulus control.

有或没有药理作用的成瘾行为：刺激控制的关键作用。

• 发表时间: 1998
• 期刊: NIDA research monograph.
• 作者: Falk,JL

Arteriovenous serum cocaine concentration difference after intravenous bolus injection and constant-rate infusions: relation to pharmacodynamic estimates in rats.

• DOI: 10.1016/s0928-0987(01)00180-4
• 发表时间: 2001-12
• 期刊: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
• 作者: L. Sun;C. Lau