BENZODIAZEPINE OVERINDULGENCE AND DRUG INTERACTIONS

(1)苯二氮类药物口服补益作用的启动 (BZS)将在滥用摄入水平的动物身上进行研究，使用一种药物 计划诱导的多饮条件下的偏爱程序。一个 口服补肾益气汤可能降低补肾益气汤的阈值 精神运动刺激剂，特别是咖啡因，阈值移动 BZ拮抗剂氟马西尼以及相关的血清药代动力学 对口服补肾益气汤的作用，将进行研究。(2)协同效应 咪达唑仑与咖啡因联合应用对细小脑损伤的作用 运动任务的表现将使用各种自发的分析 和程序化的运动测量。这些研究可能与咖啡因有关 (和其他兴奋剂)对老年人的运动问题(特别是 跌倒)，涉及BZS，不能还原为BZ镇静作用。 BZ-黄嘌呤协同作用的行为学和药理学通用性 将被描述为。(3)增加的行为影响 在明显清除慢性疾病所致的血清咖啡因 将探讨与咪达唑仑的接触情况，可能部分 BZ停顿综合征可能与咖啡因中毒有关。(4) BZ类兴奋剂的急、慢性药代动力学研究 组合将与行为研究并行，以描绘 BZ-黄嘌呤的协同作用机理。(5)将研究一项 阿普唑仑-咖啡因相互作用可能产生协同干扰 精细电机控制，这可能与触发或 不断恶化的恐慌症。另外，补肾益气汤对茶碱的影响 将注意到与以下因素引起的震颤有关的行为影响 治疗剂量的茶碱，尤其是口服。

(1) The initiation of oral reinforcing efficacy for benzodiazepines (BZs) will be studied in animals at abusive intake levels using a drug preference procedure under schedule-induced polydipsia conditions. A possible decrease in the reinforcing threshold of oral BZs by psychomotor stimulants, particularly caffeine, a threshold shift by the BZ antagonist flumazenil, as well as the serum pharmacokinetics relevant to oral BZ reinforcing function, will be studied. (2) The synergistic action of combined midazolam and caffeine injections in disrupting fine- motor task performance will be analyzed using a variety of spontaneous and programmed motor measures. These studies may implicate caffeine (and other stimulants) in motor problems of the elderly (specifically falling) that involve BZs and are not reducible to BZ sedative action. The behavioral and pharmacologic generality of BZ-xanthine synergism will be characterized. (3) The behavioral implications of the increase in apparent clearance of serum caffeine that results from chronic exposure to midazolam will be explored with the possibility that part of the BZ discontinuance syndrome may be attributable to caffeinism. (4) Clarification of the acute and chronic pharmacokinetics of BZ-stimulant combinations will parallel behavioral studies in the delineation of the mechanism of BZ-xanthine synergism. (5) There will be study of a alprazolam-caffeine interactions for a possible synergistic disruption of fine-motor control, which might be relevant to triggering or worsening panic disorder. Also, the effect of BZs on theophylline's behavioral effects will be noted in relation to tremor produced by therapeutic doses of theophylline, particularly by the oral route.