Diabetic Heart Disease – From Left Ventricular Intramyocardial Triglyceride Accumulation to Diffuse Interstitial Fibrosis and Myocardial Dysfunction

糖尿病性心脏病 — 从左心室心肌内甘油三酯蓄积到弥漫性间质纤维化和心肌功能障碍

• 批准号: nhmrc : 1054581
• 负责人: A/Pr Arnold Ng
• 金额: $ 12.4万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/diabetic-heart-disease-myocardial-dysfunction/112404
• 关键词: Diabetic; Heart; Disease; Left; Ventricular

Type 2 diabetes is the most common endocrine disease in the world and up to 60% of diabetic patients have heart disease. Heart disease is the most expensive heath condition and biggest cause of death in Australia. Diabetic patients often accumulate fat (triglyceride) within their heart cells, leading to diabetic heart disease. The present study sought to determine if diabetic patients with increased fat within their heart cells have more scarring which eventually results heart muscle dysfunction.

2型糖尿病是世界上最常见的内分泌疾病，高达60%的糖尿病患者患有心脏病。心脏病是澳大利亚最昂贵的健康状况和最大的死亡原因。糖尿病患者经常在他们的心脏细胞内积累脂肪（甘油三酯），导致糖尿病心脏病。本研究试图确定心脏细胞内脂肪增加的糖尿病患者是否有更多的疤痕，最终导致心肌功能障碍。