LONGITUDINAL STUDIES OF ADULT COGNITIVE DEVELOPMENT

西雅图纵向研究（SLS）一直是监测成人认知发展的年龄和队列趋势的主要资源，为老年人使用的评估工具提供规范性数据，探索衰老个体差异的原因，并在纵向研究的背景下评估有针对性的认知干预措施的效果。 目前，它得到了到1998年的资助，以研究健康史与维持认知功能之间的关系，提供另一次（1998年）纵向小组的后续行动，一项家庭研究的7年后续行动，以及认知训练研究的7年和14年后续行动。 它还包括管理神经心理电池，对700名60岁以上的受试者进行ApoE测试，并招募受试者进行最终尸检。目前的延续建议有四个分组成部分：（1）完成第7波数据收集。 正在寻求资金，用于评估新的第7波840名受试者，以及基于目前资助的纵向研究后续数据收集的分析。(2)将在2000年（N = 500）和2003年（N = 400）每隔3年重复对60岁以上的老年小组成员进行神经心理评估，以获得更接近受试者死亡的指标。(3)纵向小组成员的健康史将在1998年更新，以评估行为-疾病关系随时间的变化。（四）、家庭研究。 将对第二代成员进行重新评估，以获得14年期间的数据（N = 800），并收集原始小组成员的600名孙辈的数据，以研究多代家庭在认知方面的相似性。 将采集血液样本进行ApoE基因分型和血脂分析。

The Seattle Longitudinal Study (SLS) has been a major resource for monitoring age and cohort trends in adult cognitive development, providing normative data for assessment instruments used with older adults, exploring the causes of individual differences in aging, and assessing the effects of targeted cognitive interventions within the context of a longitudinal study. It is currently funded through 1998 to study the relation between health histories and maintenance of cognitive functioning, to provide another (1998) followup of the longitudinal panels, a 7-year follow-up of a family study, and 7- and 14-year follow-ups of the cognitive training studies. It also includes the administration of a neuropsychological battery, ApoE testing of 700 subjects over the age of 60, and recruitment of subjects for eventual autopsy. The present continuation proposal has four sub-components: (1) Completion of the 7th wave data collection. Funding is sought for the assessment of a new 7th wave of 840 subjects as well as for the analyses based on the currently funded follow-up data collection in the longitudinal study. (2) Neuro-psychological assessment obtained on older panel members over age 60 will be repeated in 3-year intervals in 2000 (N = 500) and 2003 (N = 400) to obtain measures closer to subjects' death. (3) Health histories of longitudinal panel members will be updated through 1998 to assess changes in behavior-disease relationships over time. (4). Family Studies. The second generation members will be reassessed to obtain data over a 14-year period (N = 800) and data will be collected on 600 grandchildren of the original panel member to allow studies of multi-generational family similarity in cognition. Blood samples will be obtained for ApoE genotyping and lipid profiles.