CORE--TISSUE PROCESSING FACILITY

组织处理核心将负责协调拟议计划项目中分散人体组织的所有方面。组织处理核心将由核心总监安东尼·A·加斯帕里医学博士、罗伯特·罗斯博士、格利尼斯·斯科特医学顾问和一名技术助理卡罗尔·坦克女士组成。该核心的具体目标将是：1)招募患有外生殖器疣的受试者以获得疣组织；2)恢复和扩增浸润性疣淋巴细胞，用于体外免疫学研究。3)外周血淋巴细胞的加工和储存。4)血清标本的加工和保存。5)DNA-PCR-ELISA法进行HPV基因分型。6)从HPV感染组织中制备自体HPV疫苗。7)协调将组织分配给适当的调查人员。

The Tissue Processing Core will be responsible for the coordination of all aspects of dispersing human tissues for the proposed program project. The Tissue Processing Core will be composed of the Core Director, Anthony A. Gaspari, MD; Robert Rose, PhD, Glynis Scoot, MD, Consultant, and a technical associate, Ms. Carol Tanck. The Specific Aims of the core will be to: 1) Recruit subjects with external genital warts to obtain wart tissue 2) Recovery and expansion of wart-infiltrating lymphocytes for in vitro immunologic studies. 3) Processing and storage of peripheral blood lymphocytes. 4) Processing and storage of serum samples. 5) HPV Genotyping by DNA PCR-ELISA 6) Preparation of autologous HPV vaccine from HPV infected tissue. 7) Coordinate distribution of tissues to appropriate investigators.