REGULATION OF FCERI EXPRESSION

描述（改编自研究者摘要）：研究者 最近证实FceRI表达可以下调， 在人嗜碱性粒细胞上上调，似乎受IgE调节 抗体的 这种调节通过何种受体发生尚不清楚， 尽管FceRI或FceRII是合理的候选物。 第一个目标是 关于FceRI表达是否以类似的方式调节， 各种临床状况的患者，以及是否也受到监管 对肥大细胞和单核细胞的作用。 第二个目标是 FceRI表达机制的一些问题，重点是 确定在FceRI-β中是否存在协调变化，以及 - γ亚基以及密切相关的酪氨酸激酶。 的 将研究FceRI上调的功能后果， 将探索调节FceRI表达的药理学试剂。 的 第三个目标集中于确定参与IgE介导的FceRI的受体 上调。 受体上调是否与 FceRI mRNA的积累和受体基因的启动子如何 还将进行研究。

DESCRIPTION (Adapted from Investigator's abstract): The investigator has recently demonstrated that FceRI expression can be both down-regulated and up-regulated on human basophils and appears to be regulated by the IgE antibody. The receptor through which this regulation occurs is unknown, although FceRI or FceRII are reasonable candidates. The first aim addresses the question of whether FceRI expression is regulated in a similar manner in patients with various clinical conditions and whether it is regulated also on mast cells and monocytes in a similar manner. The second aim addresses some issues related to the mechanism of FceRI expression, focusing on the determination of whether there are coordinated changes in the FceRI-beta and -gamma subunits as well as closely associated tyrosine kinases. The functional consequences of FceRI up-regulation will be studied and pharmacological agents that regulate FceRI expression will be explored. The third aim focuses on determining the receptor involved in IgE-mediated FceRI upregulation. Whether receptor upregulation is associated with increased FceRI mRNA accumulation and the how the promoters for the receptor genes are regulated will also be studied.