AN ANIMAL MODEL FOR STUDYING TMJ INFLAMMATION IN RATS
AN ANIMAL MODEL FOR STUDYING TMJ INFLAMMATION IN RATS
批准号:
6205417
负责人:
LARRY L BELLINGER
金额:
$2.75万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-09-01 至 2003-05-31
关键词:
Freund's adjuvant analgesics antiinflammatory agents biomarker calcitonin gene related peptide computer simulation corticosterone disease /disorder model endorphins inflammation interleukin 1 laboratory rat mechanical stress model design /development molecular dynamics nutrient intake activity oxytocin pathologic process prognosis prostaglandin E substance P temporomandibular joint syndrome
中文摘要
描述:(改编自摘要)本提案的主要目标是
开发一种生物行为动物模型,
研究颞下颌关节炎症的实验。工作假设是,
动物饲养模式将发生变化,
完全弗氏佐剂(CFA)诱导TMJ过程中的生物学标志物
炎症喂食行为将通过一个复杂的,
高度灵敏的计算机操作的膳食模式分析(MPA)方法。在
在第一个实验中,将进一步开发一个通用模型,
MPA确定早期(CFA后+2天)和晚期的行为变化
(CFA后+42天)TMJ炎症阶段。饮食模式将与
炎症标志物的变化,包括组织学,TMJ降钙素基因
相关肽和白细胞介素-1b、三叉神经节P物质和血浆
应激激素皮质酮,b-内啡肽和催产素。第二个实验
将重复这些程序与和没有抗炎治疗。
这些实验旨在为临床医生提供非侵入性的
为颞下颌关节炎症和应激的行为学标记,提供了更客观的依据
用于患者诊断、治疗和结果评估。
英文摘要
DESCRIPTION: (Adapted from Abstract) The primary objective of this proposal is
to develop a biobehavioral animal model that will allow for better design of
experiments investigating TMJ inflammation. The working hypothesis is that
animal feeding patterns will change and will be directly correlated with
biological markers during complete Freud's adjuvant (CFA) induced TMJ
inflammation. Feeding behavior will be determined via a sophisticated and
highly sensitive method of computer operated meal pattern analyses (MPA). In
the first experiment, a generalized model will be further developed that uses
MPA to determine behavioral changes during early (+2 days after CFA) and late
(+42 days after CFA) stage TMJ inflammation. Meal patterns will be correlated
to changes in inflammatory markers including histology, TMJ calcitonin gene
related peptide and interleukin-1b, trigeminal ganglia substance P, and plasma
stress hormones corticosterone, b-endorphin and oxytocin. A second experiment
will repeat these procedures with and without anti-inflammatory treatment.
These experiments are intended to provide the clinician with a non- invasive
behavioral marker for TMJ inflammation and stress, and a more objective basis
for patient diagnosis, treatment and outcomes assessment.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Sex Steroids, and TMJ Pain
-
批准号:7840876
-
项目类别:
-
资助金额:$1.32万
-
财政年份:2009
-
负责人:LARRY L BELLINGER
-
依托单位:
Sex Steroids, and TMJ Pain
-
批准号:7365113
-
项目类别:
-
资助金额:$34.11万
-
财政年份:2005
-
负责人:LARRY L BELLINGER
-
依托单位:
Sex Steroids, and TMJ Pain
-
批准号:6921100
-
项目类别:
-
资助金额:$36.38万
-
财政年份:2005
-
负责人:LARRY L BELLINGER
-
依托单位:
Sex Steroids, and TMJ Pain
-
批准号:7033941
-
项目类别:
-
资助金额:$35.52万
-
财政年份:2005
-
负责人:LARRY L BELLINGER
-
依托单位:
Sex Steroids, and TMJ Pain
-
批准号:7178528
-
项目类别:
-
资助金额:$34.49万
-
财政年份:2005
-
负责人:LARRY L BELLINGER
-
依托单位:
海外基金