RISK FACTORS FOR PERSISTENT MACULAR EDEMA POST TREATMENT

治疗后持续性黄斑水肿的危险因素

• 批准号: 6356396
• 负责人: SUSAN E VITALE
• 金额: $ 7.7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6356396
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; clinical research; data collection methodology /evaluation; diabetic retinopathy; disease /disorder proneness /risk; edema; eye fundus photography; eye laser surgery; human subject; human therapy evaluation; image processing; photocoagulation therapy; postoperative complications; prognosis; radiobiology; statistics /biometry

DESCRIPTION: (Applicant's Abstract) Diabetic macular edema, or thickening of the retina, is a common cause of visual loss in working age Americans. The Early Treatment Diabetic. Retinopathy Study (ETDRS) showed that vision can be preserved by prompt application of laser photocoagulation to areas of thickened retina. However, although laser treatment for clinically significant macular edema has been demonstrated to reduce the risk of visual loss, it does not prevent visual loss in all treated patients. Only a 50% reduction in risk of visual loss as a result of prompt photocoagulation was seen in the ETDRS. The National Eye Institute (NEI), in its Vision Research: a National Plan 1999-2003, has identified the understanding of the pathogenesis of diabetic retinopathy and development of strategies for improved treatment of diabetic retinopathy as program objectives. Using our unique technology, developed under the auspices of the NEI, for measuring the retinal thickness at the posterior pole objectively and precisely, we collected detailed data on individuals with clinically significant macular edema. These data include objectively measured pre- and post-laser treatment maps of the retinal thickness. In addition, we have collected data to document the location of treatment spots and have detailed gradings of retinal pathology from stereo fundus photographs. We propose to extend the analysis performed under the support of the previous grant and subject these data to image processing to link the information on location of laser treatment, pathology, and objectively measured retinal thickness before and after treatment. Parameters to describe areas of significantly thickened retina, changes in retinal thickness after treatment, and distance from treatment spots and retinal pathology will be derived. Statistical analysis of risk factors for persistent or worsening of retinal thickness will be carried out, using methods to take into account the spatial correlation of these map-linked data. These analyses will help to identify factors contributing to favorable outcomes of laser treatment for macular edema, and may suggest hypotheses for altering treatment strategies that can be tested in future studies.

描述：(申请人摘要)糖尿病黄斑水肿或增厚 视网膜是美国工作年龄人群视力丧失的常见原因。这个 早期治疗糖尿病。视网膜病变研究(ETDRS)表明视力可以 通过立即对增厚的区域进行激光光凝保存 视网膜。然而，尽管激光治疗临床上有意义的黄斑 浮肿已经被证明可以降低视力丧失的风险，但它并没有 在所有接受治疗的患者中防止视力丧失。只有50%的风险降低 在ETDRS中可以看到由于即刻光凝而导致的视力丧失。这个 国家眼科研究所(NEI)的视觉研究：国家计划 1999-2003年，对糖尿病的发病机制有了明确的认识 视网膜病变与改善糖尿病治疗策略的发展 视网膜病变作为项目目标。使用我们独特的技术，在 NEI的支持，用于测量视网膜后部的厚度 POL客观而准确地收集了关于有 临床上有明显的黄斑水肿。这些数据包括客观测量的 激光治疗前后视网膜厚度图。此外，我们 已收集数据以记录治疗点的位置，并已 立体眼底照片中视网膜病理的详细分级。我们 建议延长在前一次会议支持下进行的分析 授予这些数据并对其进行图像处理，以将信息链接到 激光治疗的位置、病理和客观测量的视网膜 治疗前后的厚度。用于描述以下区域的参数 视网膜显著增厚，治疗后视网膜厚度变化， 以及距离治疗点和视网膜病理的距离将会得出。 视网膜持续或恶化危险因素的统计分析 将厚度进行计算，使用的方法要考虑到空间 这些与地图相关的数据的相关性。这些分析将有助于确定 影响激光治疗黄斑疗效的因素 水肿，并可能建议改变治疗策略的假设 在未来的研究中进行了测试。