Dietary protein-induced DNA damage in colon and consequences for colorectal oncogenesis

膳食蛋白质诱导的结肠 DNA 损伤及其对结直肠肿瘤发生的影响

• 批准号: nhmrc : 535079
• 负责人: Dr Richard Le Leu
• 金额: $ 40.33万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dietary-protein-induced-colorectal-oncogenesis/97286
• 关键词: Dietary; protein; induced; DNA; damage

This research will explore the effects of dietary protein on genetic damage to cells lining the large bowel and risk of developing colorectal cancer. We will determine the degree and type of DNA damage resulting from increased protein, the cellular response to this DNA damage, whether it increases risk for developing bowel cancer and whether it can be minimised by other foods in both an animal model and humans.

这项研究将探讨膳食蛋白质对大肠内壁细胞遗传损伤和患结直肠癌风险的影响。我们将确定蛋白质增加导致的DNA损伤的程度和类型，细胞对这种DNA损伤的反应，它是否会增加患肠癌的风险，以及是否可以通过其他食物将其降至最低，无论是在动物模型中还是在人类模型中。