DEPRIVATION EFFECTS ON CENTRAL AUDITORY SYSTEM FUNCTION

这项研究的长期目标是了解 剥夺正常的听觉体验会影响发育， 中央听觉系统（CAS）的功能，以及具体如何 剥夺会影响该系统的复杂编码特性。而 已经进行了全面、系统的研究来定义和理解 终末器官损伤导致的传入神经阻滞的影响，同样 调查声音被剥夺的方法尚待采用 正常神经支配系统的输入。这项研究将提高我们的 了解传导性听力损失对发展的影响 幼儿的言语和语言技能，以及声音处理 有类似缺陷的成年人。 这一应用阐述了一系列问题，这些问题对于 我们对这个问题的理解，并提出了一系列的实验 这将使我们深入了解由一个 传导性听力损失这些初步研究的重点是界定 剥夺对听觉神经元突触前短时程变化的影响 系统活动和代谢功能的相关测量，然后 定义CAS中可能继发于 这些功能变化。我们在此提出了一个系统的研究， 剥夺权利的后果，包括确定多单元 电生理活动和代谢功能研究，包括 CAS中的蛋白质合成、酶活性和葡萄糖利用。我们 我建议在这些研究之后，对终端场进行详细分析 第三级组织，双耳受神经支配，外侧神经元 上级橄榄核。这些研究将构成更多的框架， 详细研究突触组织和生理编码 在未来的研究中。

The long-term objective of this research is to understand the way in which deprivation of normal auditory experience affects the development and function of the central auditory system (CAS), and specifically how deprivation affects the complex coding properties of this system. While comprehensive, systematic studies have been done to define and understand the effects of deafferentation resulting from end organ damage, the same approach has yet to be applied to investigation of deprivation of sound input in a normally innervated system. This research will enhance our understanding of the impact of conductive hearing loss on the development of speech and language skills in the young child, and on sound processing in adults with similar deficits. This application formulates a series of questions which are critical to our understanding of this problem, and proposes a series of experiments which will give insight into the nature of the deficit created by a conductive hearing loss. The focus of these initial studies is on defining the effect of deprivation on short term presynaptic changes in auditory system activity and associated measures of metabolic function, and then defining structural modifications in the CAS that may occur secondary to these functional changes. We propose herein a systematic study of the consequences of deprivation, including determination of multiunit electrophysiologic activity and a study of metabolic function, including protein synthesis, enzyme activity, and glucose utilization in the CAS. We propose to follow these studies with a detailed analysis of terminal field organization in third order, binaurally innervated, neurons of the lateral superior olivary nucleus. These studies will form the framework for more detailed studies of synaptic organization and physiological coding properties in future studies.