RADIOTHERAPY OF HSV-TK TRANSDUCED TUMOR BY A-VIRAL AGENT

A病毒剂对HSV-TK转导肿瘤的放射治疗

• 批准号: 6130423
• 负责人: JAE HO KIM
• 金额: $ 31.6万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2002-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6130423
• 关键词: Adenoviridae; DNA binding protein; Herpes simplex disease; antiviral agents; combination cancer therapy; fluorouracil; gene therapy; glioma; ionizing radiation; laboratory rat; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplastic cell; nonhuman therapy evaluation; oxidoreductase; p53 gene /protein; prodrugs; radiation resistance; radiation sensitivity; radiobiology; ribonucleotide reductase; tissue /cell culture; transfection /expression vector; uracil analog; virus genetics

项目成果

Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.

双自杀融合基因转导脑内 9L 神经胶质瘤的选择性放射增敏作用。

• 发表时间: 1998
• 期刊: The cancer journal from Scientific American.
• 作者: Kim,JH;Kolozsvary,A;Rogulski,K;Khil,MS;Brown,SL;Freytag,SO
• 通讯作者: Freytag,SO

Enhanced apoptosis and radiosensitization by combined 13-cis-retinoic acid and interferon-alpha2a; role of RAR-beta gene.

13-顺式视黄酸和干扰素-α2a 组合可增强细胞凋亡和放射增敏作用；

• DOI: 10.1016/s0360-3016(01)01718-7
• 发表时间: 2001
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Ryu,S;Stein,JP;Chung,CT;Lee,YJ;Kim,JH
• 通讯作者: Kim,JH

Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor.

• 发表时间: 2002-08
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Y. Lew;A. Kolozsvary;Stephen Brown;J. H. Kim

Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy.

双自杀基因治疗的显着抗肿瘤作用和肿瘤放射增敏作用。

• 发表时间: 1997
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research.
• 作者: Rogulski,KR;Zhang,K;Kolozsvary,A;Kim,JH;Freytag,SO
• 通讯作者: Freytag,SO

The potentiation of radiation response in human colon carcinoma cells in vitro and murine lymphoma in vivo by AG337 (Thymitaq), a novel thymidylate synthase inhibitor.

AG337 (Thymitaq)（一种新型胸苷酸合酶抑制剂）在体外增强人结肠癌细胞和体内小鼠淋巴瘤的放射反应。

• DOI: 10.1016/s0360-3016(98)00338-1
• 发表时间: 1998
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Kim,SH;Brown,SL;Kim,JH
• 通讯作者: Kim,JH