Targeting pathogenic TAR DNA-binding protein 43 to treat frontotemporal dementia and motor neuron disease

靶向致病性 TAR DNA 结合蛋白 43 治疗额颞叶痴呆和运动神经元疾病

• 批准号: nhmrc : 2001572
• 金额: $ 68.74万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-pathogenic-tar-neuron-disease/1779804
• 关键词: Targeting; pathogenic; TAR; DNA; binding

Frontotemporal dementia and motor neuron Disease are rapidly progressive and fatal neurodegenerative diseases that affect people in their prime. Poor understanding of the processes that lead to these diseases have slowed drug development. Through innovative experimental design, we aim to decipher a novel disease mechanism that involves specific molecular interactions and translate these findings into new therapies for the diseases.

额颞叶痴呆和运动神经元疾病是影响壮年人的快速进行性和致命的神经退行性疾病。对导致这些疾病的过程缺乏了解减缓了药物开发。通过创新的实验设计，我们的目标是破译一种涉及特定分子相互作用的新型疾病机制，并将这些发现转化为疾病的新疗法。