Dietary n-3 fats and outcomes in early-onset rheumatoid arthritis

膳食 n-3 脂肪与早发性类风湿性关节炎的结果

• 批准号: nhmrc : 157970
• 负责人: A/Pr Susanna Proudman
• 金额: $ 30.25万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dietary-n-3-rheumatoid-arthritis/99881
• 关键词: Dietary; fats; outcomes; early; onset

There is considerable evidence that positive health benefits flow from increasing the dietary intake of omega-3 polyunsaturated fats. Benefits are seen in rheumatoid arthritis, other inflammatory disorders and heart disease. Previous studies of rheumatoid arthritis and dietary omega-3 fats had a common design which probably reduced the magnitude of the beneficial dietary effects. Therefore, a 'second generation' study is needed which addresses these common design issues in order to establish optimal conditions for the use of dietary omega-3 fats in therapy for rheumatoid arthritis. The current proposal will address the previous design shortcomings by changing the background diet, measuring functional disability and joint damage as well as symptoms, starting treatment in early disease before joint damage has occurred, and by regulating concurrent drug use. The study will also evaluate a novel blood test that indicates the effect of advice to increase dietary omega-3 fats upon omega-3 nutritional status. If this nutritional index correlates with more favourable outcomes, a base will have been established for guiding treatment with omega-3 fats in routine clinical situations. This study is important because dietary treatment in rheumatoid arthritis: (a) offers sufferers with rheumatoid arthritis a more active role in the life long management of their disease. (b) has no on-going cost to the government health budget, and in fact, has the potential to decrease treatment costs in rheumatoid arthritis considerably (c) has wider applicability, e.g. for prevention and treatment of other inflammatory conditions and heart disease (d) needs to be tested with modern treatment protocols that involve multiple therapies started early in the course of rheumatoid arthritis, before irreversible impairment and disability has occurred (e) requires a nutritional index to guide treatment (f) must be evidence based.

有相当多的证据表明，积极的健康益处来自增加omega-3多不饱和脂肪的饮食摄入量。在类风湿性关节炎、其他炎症性疾病和心脏病中可以看到益处。以前的研究类风湿性关节炎和饮食中的欧米茄-3脂肪有一个共同的设计，这可能会减少有益的饮食效果的大小。因此，需要进行“第二代”研究，解决这些常见的设计问题，以建立使用膳食omega-3脂肪治疗类风湿性关节炎的最佳条件。目前的提案将通过改变背景饮食、测量功能残疾和关节损伤以及症状、在关节损伤发生前的早期疾病中开始治疗以及通过规范并发药物使用来解决先前的设计缺陷。该研究还将评估一种新的血液测试，该测试表明增加膳食omega-3脂肪对omega-3营养状况的影响。如果这一营养指数与更有利的结果相关，则将为在常规临床情况下指导omega-3脂肪治疗奠定基础。这项研究是重要的，因为类风湿关节炎的饮食治疗：（a）为类风湿关节炎患者提供了更积极的作用，使其终身管理疾病。(b)对政府卫生预算没有持续的成本，并且事实上，具有相当大地降低类风湿性关节炎的治疗成本的潜力（c）具有更广泛的适用性，例如用于预防和治疗其它炎性病症和心脏病（d）需要用现代治疗方案进行测试，所述现代治疗方案涉及在类风湿性关节炎病程早期开始的多种疗法，在发生不可逆转的损伤和残疾之前（e）需要营养指数来指导治疗（f）必须以证据为基础。