Identification of microRNAs in Scleroderma

硬皮病中 microRNA 的鉴定

• 批准号: nhmrc : 626945
• 负责人: A/Pr Susanna Proudman
• 金额: $ 28.73万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-micrornas-scleroderma/77090
• 关键词: Identification; microRNAs; Scleroderma

Scleroderma or systemic sclerosis is a debilitating disease that is characterised by fibrosis of multiple organs leading to organ failure and eventually death. There is currently no cure for the disease. We are beginning to find that a newly-discovered class of molecules, called microRNAs, regulate many disease states but its role in scleroderma has not been established. We aim in this study to identify disease-related changes in microRNAs which may subsequently be used as therapeutic targets.

硬皮病或系统性硬化症是一种使人衰弱的疾病，其特征是多个器官纤维化，导致器官衰竭并最终死亡。目前还没有治愈这种疾病的方法。我们开始发现一类新发现的分子，称为microrna，调节许多疾病状态，但其在硬皮病中的作用尚未确定。在这项研究中，我们的目的是确定microrna的疾病相关变化，这些变化可能随后被用作治疗靶点。