Transatlantic Initiative for Nanotechnology and the Environment

跨大西洋纳米技术与环境倡议

• 批准号: NE/H013679/1
• 负责人: Stephen Paul McGrath
• 金额: $ 59.1万
• 依托单位: Rothamsted Research
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FH013679%2F1
• 关键词: Transatlantic; Initiative; Nanotechnology; Environment

We have developed a life cycle perspective inspired conceptual model (CM) that suggests the importance of terrestrial ecosystems as a major repository of ZnO, TiO2, and Ag (Tier 1) manufactured nanomaterials (MNMs) introduced via the land application of MNM-containing biosolids. We propose to investigate the transport, fate, behavior, bioavailability, and effects of MNMs in(to) agroecosystems under environmentally realistic scenarios organized around three key hypotheses: Hypothesis (H1) Surface chemistry is the primary factor influencing the fate and transport of MNMs in the terrestrial environment as well as the bioavailability and effects to biological receptors; Hypothesis (H2) Once released to the environment, pristine MNM surfaces will be modified by interactions with organic and inorganic ligands (macromolecules) or via other biogeochemical transformations (aging effects forming a-MNMs); Hypothesis (H3) Ecoreceptors will respond to interactions with pristine metal and metal oxide MNMs, a-MNMs, and/or dissolved constituent metal ions and bulk oxides by specific ecological and toxicogenomic responses that will reflect their combined effects. Experimental Approach: Detailed physicochemical characterization will be conducted on Tier 1 and Tier 2 (CeO2, carbon nanotubes) MNMs and a-MNMs produced by simulating aging and these materials will be utilized in column transport (Tier 1 and 2), bioavailability, and effects (Tier 1) studies to key ecoreceptors (bacteria, soil invertebrates, and plants). Data needed to calibrate and validate the pBRM will be collected for Tier 1 MNMs using a subset of ecoreceptor species. The CM and model results from the simulated aging of MNMs will then be validated by repeating studies of Tier 1 MNMs subjected to actual WWTP using a pilot scale WWT facility. To facilitate these and future investigations of MNMs under environmentally relevant scenarios, novel in situ tools will be developed. Expected Results: The proposed research will generate among the first data on the transformations of important classes of MNMs subjected to WWTP as well as those added to and aged in soil. These data will be critical for evaluating potential direct and indirect ecological and human health risks of MNMs introduced to agroecosystems. Data generated on the simulated aged materials and on the MNM containing biosolids and soils to test H1 & H2, may indicate that the permutations of MNM properties required to be experimentally considered under realistic environmental scenarios can be significantly reduced. Furthermore, the results of this work will provide the first validation of using gene and protein expression profiles generated in laboratory controlled experiments as an indicator of exposure or effects under environmentally realistic conditions. An important output from the proposed research and modeling efforts will be the development of first generation validated predictive models of the environmental fate, behavior, bioavailability, and effects of several important classes of MNMs in agroecosystems.

我们开发了一个受生命周期视角启发的概念模型 (CM)，该模型表明陆地生态系统作为通过含 MNM 生物固体的土地应用引入的 ZnO、TiO2 和 Ag（第 1 层）人造纳米材料 (MNM) 的主要储存库的重要性。我们建议围绕三个关键假设，研究环境现实情景下 MNM 在农业生态系统中的运输、命运、行为、生物利用度和影响： 假设 (H1) 表面化学是影响 MNM 在陆地环境中的命运和运输以及生物利用度和对生物受体影响的主要因素；假设 (H2) 一旦释放到环境中，原始的 MNM 表面将通过与有机和无机配体（大分子）的相互作用或通过其他生物地球化学转化（形成 a-MNM 的老化效应）而发生改变；假设 (H3) 生态感受器将通过反映其综合效应的特定生态和毒理学响应来响应与原始金属和金属氧化物 MNM、a-MNM 和/或溶解的成分金属离子和本体氧化物的相互作用。实验方法：将对通过模拟老化产生的第 1 层和第 2 层（CeO2、碳纳米管）MNM 和 a-MNM 进行详细的物理化学表征，这些材料将用于关键生态感受器（细菌、土壤无脊椎动物和植物）的柱运输（第 1 层和第 2 层）、生物利用度和效应（第 1 层）研究。将使用生态感受器物种的子集为第 1 层 MNM 收集校准和验证 pBRM 所需的数据。然后，将通过使用中试规模污水处理设施对经过实际污水处理厂的 1 级 MNM 进行重复研究来验证 MNM 模拟老化的 CM 和模型结果。为了促进这些和未来在环境相关情景下对 MNM 的研究，将开发新颖的原位工具。预期结果：拟议的研究将产生关于受污水处理厂影响的重要类别的 MNM 以及添加到土壤中并在土壤中老化的 MNM 的转化的首批数据。这些数据对于评估引入农业生态系统的 MNM 的潜在直接和间接生态和人类健康风险至关重要。在模拟老化材料和含有生物固体和土壤的 MNM 上生成的用于测试 H1 和 H2 的数据可能表明，在现实环境场景下需要通过实验考虑的 MNM 属性的排列可以显着减少。此外，这项工作的结果将首次验证使用实验室控制实验中生成的基因和蛋白质表达谱作为环境现实条件下暴露或影响的指标。拟议的研究和建模工作的一个重要成果将是开发第一代经过验证的预测模型，这些模型涉及农业生态系统中几类重要的 MNM 的环境命运、行为、生物利用度和影响。

项目成果

Fate of Zinc Oxide and Silver Nanoparticles in a Pilot Wastewater Treatment Plant and in Processed Biosolids

• DOI: 10.1021/es403646x
• 发表时间: 2014-01-07
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Ma, Rui;Levard, Clement;Lowry, Gregory V.
• 通讯作者: Lowry, Gregory V.

Soil properties influence the toxicity and availability of Zn from ZnO nanoparticles to earthworms

土壤特性影响 ZnO 纳米粒子对蚯蚓的毒性和有效性

• DOI: 10.1016/j.envpol.2022.120907
• 发表时间: 2023
• 期刊: Environmental Pollution
• 影响因子: 8.9
• 作者: Lahive E

Advancing the Understanding of Environmental Transformations, Bioavailability and Effects of Nanomaterials, an International US Environmental Protection Agency-UK Environmental Nanoscience Initiative Joint Program.

• DOI: 10.4236/jep.2018.94025
• 发表时间: 2018-04-02
• 期刊: Journal of environmental protection
• 作者: Lasat MM;Chung KF;Lead J;McGrath S;Owen RJ;Rocks S;Unrine J;Zhang J
• 通讯作者: Zhang J

Brochure entitled "Trans-Atlantic initiative for nanomaterials in the environment"

题为“环境中纳米材料跨大西洋倡议”的小册子

• 发表时间: 2015
• 作者: McGrath, S.P.

Sewage sludge treated with metal nanomaterials inhibits earthworm reproduction more strongly than sludge treated with metal metals in bulk/salt forms

• DOI: 10.1039/c6en00280c
• 发表时间: 2017-01
• 期刊: Environmental science. Nano
• 作者: E. Lahive;M. Matzke;M. Durenkamp;A. Lawlor;S. Thacker;M. Pereira;D. Spurgeon;J. Unrine;C. Svendsen;S. Lofts