CORE--ANALYTICAL FACILITY /ONE CARBON METABOLISM

描述（改编自应用程序）：建立 新的核心实验室致力于一碳代谢是巨大的电流 在这一领域的研究兴趣，不仅营养科学家，而且 在广大公众中。这是两个主要发展的结果， 近几年的营养研究。首先是认可度 大约75%的神经管缺陷的出生可以通过以下方法预防： 孕期补充叶酸。第二个发展是 血浆同型半胱氨酸水平升高作为独立风险的鉴定 血管疾病的因素。自1997年1月以来， 1300篇关于叶酸的期刊文章和700多篇关于 同型半胱氨酸在范德比尔特我们很幸运有一群调查员 他们是叶酸和一碳代谢研究的领导者。的 推动建立一碳核心的动力是希望使这一点 其他CNRU调查人员的专业知识。 很明显，高胱氨酸尿症患者的血浆中 如果不治疗，高半胱氨酸在早期发展成血管闭塞性疾病。 最近，注意力已经集中在中度升高的患者上。 同型半胱氨酸水平（高同型半胱氨酸血症）及其相关性 心血管、脑血管和外周血管疾病一直是 确立了习甚至最近，血浆同型半胱氨酸水平的增加， 肾病患者认为，这可能与高 冠心病在这组患者中的发病率。此外，本发明还提供了一种方法， 血浆同型半胱氨酸已显示在患者中显著升高 阿尔茨海默氏症和阿尔茨海默氏症类型的痴呆症。

DESCRIPTION (adapted from the application): The rationale for establishing a new Core Laboratory devoted to One-carbon Metabolism is the enormous current interest in this area of research, not only by nutritional scientists, but also among the public at large. This is a result of two major developments in Nutritional Research over the past several years. The first is the recognition that about 75% of all births with neural tube defects may be prevented by periconceptional supplementation with folic acid. The second development is the identification of elevated plasma homocysteine levels as an independent risk factor for vascular disease. Since January 1997 there have been published over 1300 journal articles about folic acid and over 700 articles about homocysteine. At Vanderbilt we are fortunate to have a group of investigators who are among the leaders in studies of folate and one-carbon metabolism. The impetus to establish the one-carbon Core has been the desire to make this expertise available to other CNRU investigators. It is clear that patients with homocystinuria having very high levels of plasma homocysteine develop vascular occlusive disease at an early age if untreated. Recently, attention has been focused on patients with moderately elevated homocysteine levels (hyperhomocysteinemia) and an association with cardiovascular, cerebrovascular and peripheral vascular disease has been established. Even more recently, the increased levels of plasma homocysteine in patients with renal disease has suggested that this may be related to the high incidence of coronary heart disease in this group of patients. In addition, plasma homocysteine has been shown to be significantly elevated in patients with Alzheimer's disease and in dementia of Alzheimer's type.